Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

Kiichi Hirota; Gregg L. Semenza

doi:10.1016/j.bbrc.2005.08.193

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

Kiichi Hirota, Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Review article › peer-review

186 Scopus citations

Abstract

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.

Original language	English (US)
Pages (from-to)	610-616
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	338
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2005.08.193
State	Published - Dec 9 2005

Keywords

Dioxygenase
Hydroxylation
Hypoxia
Hypoxia-inducible factor 1
Oxygen sensing
Transcriptional regulation

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2005.08.193

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title = "Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases",

abstract = "Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.",

keywords = "Dioxygenase, Hydroxylation, Hypoxia, Hypoxia-inducible factor 1, Oxygen sensing, Transcriptional regulation",

author = "Kiichi Hirota and Semenza, {Gregg L.}",

note = "Funding Information: Work in the authors{\textquoteright} laboratories is supported in part by grants from the National Institutes of Health (to G.L.S.) and by a Grant-in-Aid for scientific research from Ministry of Education, Culture, Sports, Science and Technology (to K.H.). The authors regret that not all important papers could be cited due to space limitations.",

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AU - Hirota, Kiichi

AU - Semenza, Gregg L.

N1 - Funding Information: Work in the authors’ laboratories is supported in part by grants from the National Institutes of Health (to G.L.S.) and by a Grant-in-Aid for scientific research from Ministry of Education, Culture, Sports, Science and Technology (to K.H.). The authors regret that not all important papers could be cited due to space limitations.

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N2 - Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.

AB - Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.

KW - Dioxygenase

KW - Hydroxylation

KW - Hypoxia

KW - Hypoxia-inducible factor 1

KW - Oxygen sensing

KW - Transcriptional regulation

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Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

Abstract

Keywords

ASJC Scopus subject areas

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