Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: Implications for multiple sclerosis

Klemens Ruprecht, Karola Obojes, Verena Wengel, Felix Gronen, Kwang Sik Kim, Hervé Perron, Jürgen Schneider-Schaulies, Peter Rieckmann

Research output: Contribution to journalArticlepeer-review

Abstract

The multiple sclerosis-associated retrovirus (MSRV), originally identified in cell cultures from patients with multiple sclerosis (MS), is closely related to the human endogenous retrovirus family W (HERV-W). Recently, HERV-W gag and env protein expression was demonstrated in MS lesions in situ. Here, the authors show that HERV-W gag and env proteins are induced by herpes simplex virus type 1 (HSV-1) in neuronal and brain endothelial cells in vitro. The transactivation of HERV-W proteins by HSV-1 could enhance their potential oligodendrotoxic and immunopathogenic effects, representing a mechanism by which HSV-1, and possibly also other herpesviruses associated with MS, may be linked to the pathogenesis of this disease.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalJournal of neurovirology
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2006

Keywords

  • Cerebral endothelial cells
  • Herpes simplex virus type 1
  • Human endogenous retrovirus W
  • IMR-32
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Fingerprint Dive into the research topics of 'Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: Implications for multiple sclerosis'. Together they form a unique fingerprint.

Cite this