Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: Implications for multiple sclerosis

Klemens Ruprecht, Karola Obojes, Verena Wengel, Felix Gronen, Kwang Sik Kim, Hervé Perron, Jürgen Schneider-Schaulies, Peter Rieckmann

Research output: Contribution to journalArticle

Abstract

The multiple sclerosis-associated retrovirus (MSRV), originally identified in cell cultures from patients with multiple sclerosis (MS), is closely related to the human endogenous retrovirus family W (HERV-W). Recently, HERV-W gag and env protein expression was demonstrated in MS lesions in situ. Here, the authors show that HERV-W gag and env proteins are induced by herpes simplex virus type 1 (HSV-1) in neuronal and brain endothelial cells in vitro. The transactivation of HERV-W proteins by HSV-1 could enhance their potential oligodendrotoxic and immunopathogenic effects, representing a mechanism by which HSV-1, and possibly also other herpesviruses associated with MS, may be linked to the pathogenesis of this disease.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalJournal of NeuroVirology
Volume12
Issue number1
DOIs
StatePublished - Feb 2006

Fingerprint

Retroviridae Proteins
Endogenous Retroviruses
Human Herpesvirus 1
Multiple Sclerosis
env Gene Products
gag Gene Products
Herpesviridae
Retroviridae
Transcriptional Activation
Endothelial Cells
Cell Culture Techniques
Brain
Proteins

Keywords

  • Cerebral endothelial cells
  • Herpes simplex virus type 1
  • Human endogenous retrovirus W
  • IMR-32
  • Multiple sclerosis

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1 : Implications for multiple sclerosis. / Ruprecht, Klemens; Obojes, Karola; Wengel, Verena; Gronen, Felix; Kim, Kwang Sik; Perron, Hervé; Schneider-Schaulies, Jürgen; Rieckmann, Peter.

In: Journal of NeuroVirology, Vol. 12, No. 1, 02.2006, p. 65-71.

Research output: Contribution to journalArticle

Ruprecht, Klemens ; Obojes, Karola ; Wengel, Verena ; Gronen, Felix ; Kim, Kwang Sik ; Perron, Hervé ; Schneider-Schaulies, Jürgen ; Rieckmann, Peter. / Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1 : Implications for multiple sclerosis. In: Journal of NeuroVirology. 2006 ; Vol. 12, No. 1. pp. 65-71.
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