Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by andronergic-anabolic steroids

Rexford S. Ahima, Richard E. Harlan

Research output: Contribution to journalArticlepeer-review

Abstract

To determine whether androenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.

Original languageEnglish (US)
Pages (from-to)311-314
Number of pages4
JournalBrain research
Volume585
Issue number1-2
DOIs
StatePublished - Jul 10 1992
Externally publishedYes

Keywords

  • Androgenic-anabolic steroid
  • Glucocorticoid receptor
  • Hippocampus
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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