Regulation of estrogen receptor α function in breast cancer

Anne T. Ferguson, Nancy E. Davidson

Research output: Contribution to journalReview articlepeer-review

Abstract

Estrogen receptor α (ER) plays a key role in the development and progression of breast cancer as well as the treatment and outcome of breast cancer patients. In normal mammary epithelial cells, the level of ER fluctuates during the menstrual cycle in response to cyclical changes in estrogen. However, in breast cancer normal control of ER gene expression and/or function is lost. Of particular interest, the absence of ER in mammary carcinomas is associated with a less-differentiated phenotype and resistance to endocrine therapies. This review focuses on our current understanding of the mechanisms that regulate ER α gene expression and function in breast cancer. These include alteration of the ER gene, loss of gene expression, alternative splicing of ER RNA, posttranslational modification of the protein, and interaction of ER with other proteins that can modify its function.

Original languageEnglish (US)
Pages (from-to)29-46
Number of pages18
JournalCritical reviews in oncogenesis
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1997

Keywords

  • Alternative splicing
  • Coactivators
  • Methylation
  • Mutation
  • Phosphorylation
  • Transcription

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Regulation of estrogen receptor α function in breast cancer'. Together they form a unique fingerprint.

Cite this