Regulation of energy consumption in the cardiac muscle

A. Landesberg, R. Beyar, S. Sideman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The biochemical-mechanical basis for the well known linear relationship between left ventricular (LV) oxygen consumption and generated mechanical energy is established here. Biochemical studies and the analysis of calcium kinetics suggest a positive feedback mechanism, the cooperativity, whereby the affinity of the regulatory proteins for calcium depends on the number of force producing crossbridges (Xbs). The mechanical energy, quantified by the force-length area (FLA) or by the force-time integral (FTI) for isometric regime is in excellent correlation with the calculated energy consumption. The cooperativity regulates crossbridge ATPases recruitment, hence the rate of energy consumption and the generated force, thus providing the molecular basis for the regulation of cardiac muscle economy.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherIEEE
Pages51-54
Number of pages4
StatePublished - 1995
Externally publishedYes
EventProceedings of the 1995 Conference on Computers in Cardiology - Vienna, Austria
Duration: Sep 10 1995Sep 13 1995

Other

OtherProceedings of the 1995 Conference on Computers in Cardiology
CityVienna, Austria
Period9/10/959/13/95

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

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    Landesberg, A., Beyar, R., & Sideman, S. (1995). Regulation of energy consumption in the cardiac muscle. In Computers in Cardiology (pp. 51-54). IEEE.