Regulation of Copper Transporters in Human Cells

Nesrin M. Hasan, Svetlana Lutsenko

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Copper is essential for normal growth and development of human organisms. The role of copper as a cofactor of important metabolic enzymes, such as cytochrome c oxidase, superoxide dismutase, lysyl oxidase, dopamine-β-hydroxylase, and many others, has been well established. In recent years, new regulatory roles of copper have emerged. Accumulating evidence points to the involvement of copper in lipid metabolism, antimicrobial defense, neuronal activity, resistance of tumor cells to platinum-based chemotherapeutic drugs, kinase-mediated signal transduction, and other essential cellular processes. For many of these processes, the precise mechanism of copper action remains to be established. Nevertheless, it is increasingly clear that many regulatory and signaling events are associated with changes in the intracellular localization and abundance of copper transporters, as well as distinct compartmentalization of copper itself. In this review, we discuss current data on regulation of the localization and abundance of copper transporters in response to metabolic and signaling events in human cells. Regulation by kinase-mediated phosphorylation will be addressed along with the emerging area of the redox-driven control of copper transport. We highlight mechanistic questions that await further testing.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Membranes
PublisherAcademic Press Inc.
Pages137-161
Number of pages25
DOIs
StatePublished - 2012

Publication series

NameCurrent Topics in Membranes
Volume69
ISSN (Print)1063-5823

Keywords

  • ATP7A
  • ATP7B
  • Copper
  • HCTR1
  • Trafficking

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Hasan, N. M., & Lutsenko, S. (2012). Regulation of Copper Transporters in Human Cells. In Current Topics in Membranes (pp. 137-161). (Current Topics in Membranes; Vol. 69). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-394390-3.00006-9