Regulation of Chromatin Structure and Gene Activity by Poly(ADP-Ribose) Polymerases

Alexei Tulin; Yurii Chinenov; Allan Spradling

doi:10.1016/S0070-2153(03)01007-X

Regulation of Chromatin Structure and Gene Activity by Poly(ADP-Ribose) Polymerases

Alexei Tulin, Yurii Chinenov, Allan Spradling

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays an important role in repairing DNA and responding to infection. Here we review recent evidence that PARP1 and related proteins also carry out crucial functions regulating genes during normal development. Genetic studies in mammals and Drosophila have implied that PARPs mediate rapid responses to environmental stimuli, including infection, stress, hormones, and growth signals. In addition, these polymerases may control fundamental processes that differentially mold and remodel chromatin within the many cell types of a developing embryo. We discuss a unified mechanism of PARP action during DNA repair, gene transcription, and chromatin modulation.

Original language	English (US)
Title of host publication	Current Topics in Developmental Biology
Pages	55-83
Number of pages	29
Volume	56
DOIs	https://doi.org/10.1016/S0070-2153(03)01007-X
State	Published - 2003
Externally published	Yes

Publication series

Name	Current Topics in Developmental Biology
Volume	56
ISSN (Print)	00702153

ASJC Scopus subject areas

Developmental Biology

Access to Document

10.1016/S0070-2153(03)01007-X

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abstract = "Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays an important role in repairing DNA and responding to infection. Here we review recent evidence that PARP1 and related proteins also carry out crucial functions regulating genes during normal development. Genetic studies in mammals and Drosophila have implied that PARPs mediate rapid responses to environmental stimuli, including infection, stress, hormones, and growth signals. In addition, these polymerases may control fundamental processes that differentially mold and remodel chromatin within the many cell types of a developing embryo. We discuss a unified mechanism of PARP action during DNA repair, gene transcription, and chromatin modulation.",

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AU - Spradling, Allan

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AB - Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays an important role in repairing DNA and responding to infection. Here we review recent evidence that PARP1 and related proteins also carry out crucial functions regulating genes during normal development. Genetic studies in mammals and Drosophila have implied that PARPs mediate rapid responses to environmental stimuli, including infection, stress, hormones, and growth signals. In addition, these polymerases may control fundamental processes that differentially mold and remodel chromatin within the many cell types of a developing embryo. We discuss a unified mechanism of PARP action during DNA repair, gene transcription, and chromatin modulation.

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