TY - CHAP
T1 - Regulation of Chromatin Structure and Gene Activity by Poly(ADP-Ribose) Polymerases
AU - Tulin, Alexei
AU - Chinenov, Yurii
AU - Spradling, Allan
PY - 2003
Y1 - 2003
N2 - Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays an important role in repairing DNA and responding to infection. Here we review recent evidence that PARP1 and related proteins also carry out crucial functions regulating genes during normal development. Genetic studies in mammals and Drosophila have implied that PARPs mediate rapid responses to environmental stimuli, including infection, stress, hormones, and growth signals. In addition, these polymerases may control fundamental processes that differentially mold and remodel chromatin within the many cell types of a developing embryo. We discuss a unified mechanism of PARP action during DNA repair, gene transcription, and chromatin modulation.
AB - Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays an important role in repairing DNA and responding to infection. Here we review recent evidence that PARP1 and related proteins also carry out crucial functions regulating genes during normal development. Genetic studies in mammals and Drosophila have implied that PARPs mediate rapid responses to environmental stimuli, including infection, stress, hormones, and growth signals. In addition, these polymerases may control fundamental processes that differentially mold and remodel chromatin within the many cell types of a developing embryo. We discuss a unified mechanism of PARP action during DNA repair, gene transcription, and chromatin modulation.
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U2 - 10.1016/S0070-2153(03)01007-X
DO - 10.1016/S0070-2153(03)01007-X
M3 - Chapter
C2 - 14584726
AN - SCOPUS:2142829614
SN - 0121531562
SN - 9780121531560
VL - 56
T3 - Current Topics in Developmental Biology
SP - 55
EP - 83
BT - Current Topics in Developmental Biology
ER -