Regulation of Chromatin Structure and Gene Activity by Poly(ADP-Ribose) Polymerases

Alexei Tulin, Yurii Chinenov, Allan Spradling

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays an important role in repairing DNA and responding to infection. Here we review recent evidence that PARP1 and related proteins also carry out crucial functions regulating genes during normal development. Genetic studies in mammals and Drosophila have implied that PARPs mediate rapid responses to environmental stimuli, including infection, stress, hormones, and growth signals. In addition, these polymerases may control fundamental processes that differentially mold and remodel chromatin within the many cell types of a developing embryo. We discuss a unified mechanism of PARP action during DNA repair, gene transcription, and chromatin modulation.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
Pages55-83
Number of pages29
Volume56
DOIs
StatePublished - 2003
Externally publishedYes

Publication series

NameCurrent Topics in Developmental Biology
Volume56
ISSN (Print)00702153

ASJC Scopus subject areas

  • Developmental Biology

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