Abstract
Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. However, certain cell populations maintain cell proliferation in the face of hypoxia. This is a common pathological hallmark of cancers, but can also serve a physiological function, as in the maintenance of stem cell populations that reside in a hypoxic niche. This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors.
Original language | English (US) |
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Pages (from-to) | C775-C782 |
Journal | American Journal of Physiology - Cell Physiology |
Volume | 309 |
Issue number | 12 |
DOIs | |
State | Published - Dec 15 2015 |
Keywords
- Cell cycle
- Chaperonemediated autophagy
- Cyclin-dependent kinases
- Hematopoietic stem cells
- Hypoxia-inducible factor-1
- Minichromosome maintenance helicase
- Neural stem cells
ASJC Scopus subject areas
- Physiology
- Cell Biology