Abstract
Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. However, certain cell populations maintain cell proliferation in the face of hypoxia. This is a common pathological hallmark of cancers, but can also serve a physiological function, as in the maintenance of stem cell populations that reside in a hypoxic niche. This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | C775-C782 |
| Journal | American Journal of Physiology - Cell Physiology |
| Volume | 309 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 15 2015 |
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Keywords
- Cell cycle
- Chaperonemediated autophagy
- Cyclin-dependent kinases
- Hematopoietic stem cells
- Hypoxia-inducible factor-1
- Minichromosome maintenance helicase
- Neural stem cells
ASJC Scopus subject areas
- Cell Biology
- Physiology
Cite this
Regulation of cell proliferation by hypoxia-inducible factors. / Hubbi, Maimon E.; Semenza, Gregg L.
In: American Journal of Physiology - Cell Physiology, Vol. 309, No. 12, 15.12.2015, p. C775-C782.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Regulation of cell proliferation by hypoxia-inducible factors
AU - Hubbi, Maimon E.
AU - Semenza, Gregg L
PY - 2015/12/15
Y1 - 2015/12/15
N2 - Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. However, certain cell populations maintain cell proliferation in the face of hypoxia. This is a common pathological hallmark of cancers, but can also serve a physiological function, as in the maintenance of stem cell populations that reside in a hypoxic niche. This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors.
AB - Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. However, certain cell populations maintain cell proliferation in the face of hypoxia. This is a common pathological hallmark of cancers, but can also serve a physiological function, as in the maintenance of stem cell populations that reside in a hypoxic niche. This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors.
KW - Cell cycle
KW - Chaperonemediated autophagy
KW - Cyclin-dependent kinases
KW - Hematopoietic stem cells
KW - Hypoxia-inducible factor-1
KW - Minichromosome maintenance helicase
KW - Neural stem cells
UR - http://www.scopus.com/inward/record.url?scp=84979971910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84979971910&partnerID=8YFLogxK
U2 - 10.1152/ajpcell.00279.2015
DO - 10.1152/ajpcell.00279.2015
M3 - Review article
VL - 309
SP - C775-C782
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6135
IS - 12
ER -