Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

Fumin Chang, Linda S. Steelman, John G. Shelton, John T. Lee, Patrick M. Navolanic, William L. Blalock, Richard Franklin, James A. McCubrey

Research output: Contribution to journalReview articlepeer-review

Abstract

The Ras/Raf/MEK/ERK signal transduction pathway regulates cell cycle progression and apoptosis in diverse types of cells. Mutations in this pathway are often observed in transformed cell lines and frequently linked with human cancers. The Ras/Raf/MEK/ERK pathway can induce events both associated with cell proliferation and cell cycle arrest. The particular course chosen may depend on the strength and the particular Raf gene activated by Ras. This pathway also is involved in maintaining cell survival by modulating the activity of apoptotic molecules including Bad and Bcl-2. This review will discuss the regulation of the Ras/Raf/MEK/ERK pathway and how it modulates cell cycle progression and cell survival.

Original languageEnglish (US)
Pages (from-to)469-480
Number of pages12
JournalInternational journal of oncology
Volume22
Issue number3
StatePublished - Mar 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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