Abstract
Left ventricular mechanical function is determined by the actin-myosin crossbridges (Xbs), which are the motor units of the muscle. Xb dynamics is regulated by a negative mechanical feedback which controls the rate of Xb turnover from strong to weak conformation. The hypothesis that the transition rate of Xb turnover is determined by the sarcomere shortening velocity is experimentally verified. LV power and external work are determined by the effect of ejection pressure development. The time varying pressure during the isovolumic beat and the time varying elastance are determined by the number of available Xbs.
Original language | English (US) |
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Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
Publisher | IEEE |
Pages | 225 |
Number of pages | 1 |
Volume | 1 |
ISBN (Print) | 0780356756 |
State | Published - 1999 |
Externally published | Yes |
Event | Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA Duration: Oct 13 1999 → Oct 16 1999 |
Other
Other | Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) |
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City | Atlanta, GA, USA |
Period | 10/13/99 → 10/16/99 |
ASJC Scopus subject areas
- Bioengineering