Regulation of cardiac pressure by ejection velocity

Amir Landesberg, Oscar Lichtenstein, Rafael Beyar, Samuel Sideman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Left ventricular mechanical function is determined by the actin-myosin crossbridges (Xbs), which are the motor units of the muscle. Xb dynamics is regulated by a negative mechanical feedback which controls the rate of Xb turnover from strong to weak conformation. The hypothesis that the transition rate of Xb turnover is determined by the sarcomere shortening velocity is experimentally verified. LV power and external work are determined by the effect of ejection pressure development. The time varying pressure during the isovolumic beat and the time varying elastance are determined by the number of available Xbs.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages225
Number of pages1
Volume1
ISBN (Print)0780356756
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Landesberg, A., Lichtenstein, O., Beyar, R., & Sideman, S. (1999). Regulation of cardiac pressure by ejection velocity. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 225). IEEE.