Regulation of cancer cell metabolism by hypoxia-inducible factor 1

Research output: Contribution to journalReview articlepeer-review

Abstract

The induction of hypoxia-inducible factor 1 (HIF-1) activity, either as a result of intratumoral hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of cancer cell metabolism involving increased glucose transport into the cell, increased conversion of glucose to pyruvate, and a concomitant decrease in mitochondrial metabolism and mitochondrial mass. Blocking these adaptive metabolic responses to hypoxia leads to cell death due to toxic levels of reactive oxygen species. Targeting HIF-1 or metabolic enzymes encoded by HIF-1 target genes may represent a novel therapeutic approach to cancer.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalSeminars in Cancer Biology
Volume19
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • BNIP3
  • Glucose transporter
  • Glycolysis
  • HIF-1
  • Lactate dehydrogenase
  • MCT4
  • Mitochondrial autophagy
  • NHE1
  • Oxygen
  • PDK1
  • Warburg effect

ASJC Scopus subject areas

  • Cancer Research

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