TY - JOUR
T1 - Regulation of cancer cell growth and death
T2 - Evaluating new anticancer targets
AU - Bunz, Fred
N1 - Funding Information:
Research in the author's laboratory is supported by the Flight Attendant Medical Research Institute and the National Institutes of Health grant CA104253.
PY - 2005
Y1 - 2005
N2 - Genes that affect the growth and death of cancer cells have obvious potential as targets for new forms of anticancer therapy. Which of these targets will give the desired result is much less obvious. Using homologous recombination to knock out genes in human cancer cells has proven to be a reliable approach for evaluating how specific genes affect cellular responses to drugs and radiation. Recent studies of this kind have revealed several genes that can modulate the responses of human cancer cells to chemopreventive agents and to established and experimental forms of anticancer therapy.
AB - Genes that affect the growth and death of cancer cells have obvious potential as targets for new forms of anticancer therapy. Which of these targets will give the desired result is much less obvious. Using homologous recombination to knock out genes in human cancer cells has proven to be a reliable approach for evaluating how specific genes affect cellular responses to drugs and radiation. Recent studies of this kind have revealed several genes that can modulate the responses of human cancer cells to chemopreventive agents and to established and experimental forms of anticancer therapy.
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U2 - 10.1016/j.ddmec.2005.08.006
DO - 10.1016/j.ddmec.2005.08.006
M3 - Review article
AN - SCOPUS:33645054296
VL - 2
SP - 383
EP - 387
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
SN - 1740-6765
IS - 3
ER -