Regulation of cancer cell growth and death: Evaluating new anticancer targets

Research output: Contribution to journalReview articlepeer-review


Genes that affect the growth and death of cancer cells have obvious potential as targets for new forms of anticancer therapy. Which of these targets will give the desired result is much less obvious. Using homologous recombination to knock out genes in human cancer cells has proven to be a reliable approach for evaluating how specific genes affect cellular responses to drugs and radiation. Recent studies of this kind have revealed several genes that can modulate the responses of human cancer cells to chemopreventive agents and to established and experimental forms of anticancer therapy.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalDrug Discovery Today: Disease Mechanisms
Issue number3
StatePublished - 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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