Regulation of calcium signaling in lung cancer

Haihong Yang, Qi Zhang, Jianxing He, Wenju Lu

Research output: Contribution to journalReview articlepeer-review


Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous cellular signal, which is crucial in cancer. This review presents regulation of calcium signaling in lung cancer. Altered expression of specific Ca2+ channels and Ca2+-binding proteins are characterizing features of lung cancer, which regulate cell signaling pathway leading to cell proliferation or apoptosis. Chemoresistance is frequent in lung cancer. Altered endoplasmic reticulum Ca2+ homeostasis of lung cancer cell is correlated with drug resistance. Hypoxia has a vital role in tumor angiogenesis, metastasis, apoptosis. And Ca2+ channels are open induced by hypoxia with the increase of Ca2+ influx causing tumor growth.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalJournal of Thoracic Disease
Issue number1
StatePublished - 2010
Externally publishedYes


  • Calcium
  • Calcium channels
  • Calcium-binding protein
  • Endoplasmic reticulum
  • Lung cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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