Regulation of calcium absorption by 1,25,dihydroxy-vitamin D-Studies of the effects of a bisphosphonate treatment

S. Adami, W. B. Frijlink, O. L M Bijvoet, J. L H O'Riordan, Thomas Clemens, S. E. Papapoulos

Research output: Contribution to journalArticle

Abstract

In 10 patients with Paget's disease of bone and 2 patients with osteoporosis, we studied the effects of hypocalcemia and hypophosphatemia induced by disodium-(3-amino-1-hydroxypropylidene)-1,-bisphosphonate (APD) treatment on the serum concentration of PTH and 1,25-dihydroxyvitamin D [1,25(OH)2D3] and on calcium absorption and balance. The fall in serum calcium and phosphate was associated with a rise in the serum concentration of PTH and 1,25(OH)2D3, coupled with increases in net calcium absorption and calcium balance. The concentration of 1,25(OH)2D3 was significantly related (P2D3 production. Moreover, the rise in 1,25(OH)2D3 caused an appropriate rise in calcium absorption (r=0.74) and calcium balance (r=0.86), showing that this vitamin D metabolite contributes as a hormone to calcium homeostasis.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalCalcified Tissue International
Volume34
Issue number1
DOIs
StatePublished - Dec 1982
Externally publishedYes

Fingerprint

Diphosphonates
Vitamin D
Calcium
pamidronate
Therapeutics
Serum
Hypophosphatemia
Osteitis Deformans
Hypocalcemia
Osteoporosis
Homeostasis
Hormones

Keywords

  • 1,25-Dihydroxy-vitamin D
  • Bisphosphonate
  • Calcium absorption
  • Parathyroid hormone

ASJC Scopus subject areas

  • Endocrinology
  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Regulation of calcium absorption by 1,25,dihydroxy-vitamin D-Studies of the effects of a bisphosphonate treatment. / Adami, S.; Frijlink, W. B.; Bijvoet, O. L M; O'Riordan, J. L H; Clemens, Thomas; Papapoulos, S. E.

In: Calcified Tissue International, Vol. 34, No. 1, 12.1982, p. 317-320.

Research output: Contribution to journalArticle

Adami, S. ; Frijlink, W. B. ; Bijvoet, O. L M ; O'Riordan, J. L H ; Clemens, Thomas ; Papapoulos, S. E. / Regulation of calcium absorption by 1,25,dihydroxy-vitamin D-Studies of the effects of a bisphosphonate treatment. In: Calcified Tissue International. 1982 ; Vol. 34, No. 1. pp. 317-320.
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