Regulation of calcium absorption by 1,25,dihydroxy-vitamin D-Studies of the effects of a bisphosphonate treatment

S. Adami, W. B. Frijlink, O. L.M. Bijvoet, J. L.H. O'Riordan, T. L. Clemens, S. E. Papapoulos

Research output: Contribution to journalArticle

Abstract

In 10 patients with Paget's disease of bone and 2 patients with osteoporosis, we studied the effects of hypocalcemia and hypophosphatemia induced by disodium-(3-amino-1-hydroxypropylidene)-1,-bisphosphonate (APD) treatment on the serum concentration of PTH and 1,25-dihydroxyvitamin D [1,25(OH)2D3] and on calcium absorption and balance. The fall in serum calcium and phosphate was associated with a rise in the serum concentration of PTH and 1,25(OH)2D3, coupled with increases in net calcium absorption and calcium balance. The concentration of 1,25(OH)2D3 was significantly related (P<0.001) to the serum calcium (r=0.66), the serum phosphate (r=0.78), and the serum PTH (r=0.71), confirming the interrelated control of these parameters on 1,25(OH)2D3 production. Moreover, the rise in 1,25(OH)2D3 caused an appropriate rise in calcium absorption (r=0.74) and calcium balance (r=0.86), showing that this vitamin D metabolite contributes as a hormone to calcium homeostasis.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalCalcified Tissue International
Volume34
Issue number1
DOIs
StatePublished - Dec 1 1982
Externally publishedYes

Keywords

  • 1,25-Dihydroxy-vitamin D
  • Bisphosphonate
  • Calcium absorption
  • Parathyroid hormone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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