Regulation of apoptosis in thymocytes

Research output: Contribution to journalReview article

Abstract

IMMATURE THYMOCYTES have served as an important model system for the study of biochemical mechanisms involved in the regulation of apoptosis (programmed cell death). From this work, it has become clear that the process is tightly regulated by cellular signaling pathways previously implicated in the control of cell proliferation and differentiation. In particular, elevations in the cytosolic Ca2+ concentration commonly trigger the response, and increases in cyclic adenosine monophosphate and activation of protein kinase C also appear to be involved. Ongoing research is aimed at characterizing how these and other signal transduction systems influence transcription and translation in apoptotic cells, as well as determining how their involvement in apoptosis differs from their role in other cellular responses.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalCancer Bulletin
Volume46
Issue number2
StatePublished - 1994
Externally publishedYes

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Thymocytes
Apoptosis
Cyclic AMP
Protein Kinase C
Cell Differentiation
Signal Transduction
Cell Death
Cell Proliferation
Research

ASJC Scopus subject areas

  • Cancer Research

Cite this

Regulation of apoptosis in thymocytes. / McConkey, David.

In: Cancer Bulletin, Vol. 46, No. 2, 1994, p. 146-152.

Research output: Contribution to journalReview article

McConkey, David. / Regulation of apoptosis in thymocytes. In: Cancer Bulletin. 1994 ; Vol. 46, No. 2. pp. 146-152.
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