Regulation of antigen-induced blastogenesis and interleukin-2 expression by adherent mononuclear cells in humans infected with Schistosoma mansoni

Jerrold J. Ellner; Carla Wilson; Zahra Toossi; Aziz El Kholy

Regulation of antigen-induced blastogenesis and interleukin-2 expression by adherent mononuclear cells in humans infected with Schistosoma mansoni

Jerrold J. Ellner, Carla Wilson, Zahra Toossi, Aziz El Kholy

Research output: Contribution to journal › Article › peer-review

Abstract

The immune response and its regulation by adherent mononuclear cells were investigated in 39 Egyptians aged 13-30 (mean ± SD, 16.2 ± 3.6) with chronic Schistosoma mansoni infection (fecal egg excretion, 40-2480 eggs/g; mean, 709 ± 612). Blastogenesis and production of interleukin-2 (IL-2) by peripheral blood mononuclear cells showed a significant correlation when streptolysin O but not when soluble worm antigenic preparation (SWAP) was used as stimulus. This suggested independent regulation of these responses to SWAP. Thirteen subjects showed SWAP-restricted suppression of blastogenesis but not IL-2 production by adherent cells. Compared with 24 other S. mansoni-infected subjects, they had depressed blastogenic responses to SWAP but comparable SWAP-induced IL-2 production and responsiveness to exogenous IL-2. This study indicates that IL-2 production is not the site of action of parasite antigen-restricted suppressor adherent cells in chronic S. mansoni infection.

Original language	English (US)
Pages (from-to)	1284-1289
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	161
Issue number	6
State	Published - Jun 1990
Externally published	Yes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Immunology

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title = "Regulation of antigen-induced blastogenesis and interleukin-2 expression by adherent mononuclear cells in humans infected with Schistosoma mansoni",

abstract = "The immune response and its regulation by adherent mononuclear cells were investigated in 39 Egyptians aged 13-30 (mean ± SD, 16.2 ± 3.6) with chronic Schistosoma mansoni infection (fecal egg excretion, 40-2480 eggs/g; mean, 709 ± 612). Blastogenesis and production of interleukin-2 (IL-2) by peripheral blood mononuclear cells showed a significant correlation when streptolysin O but not when soluble worm antigenic preparation (SWAP) was used as stimulus. This suggested independent regulation of these responses to SWAP. Thirteen subjects showed SWAP-restricted suppression of blastogenesis but not IL-2 production by adherent cells. Compared with 24 other S. mansoni-infected subjects, they had depressed blastogenic responses to SWAP but comparable SWAP-induced IL-2 production and responsiveness to exogenous IL-2. This study indicates that IL-2 production is not the site of action of parasite antigen-restricted suppressor adherent cells in chronic S. mansoni infection.",

author = "Ellner, {Jerrold J.} and Carla Wilson and Zahra Toossi and {El Kholy}, Aziz",

year = "1990",

month = jun,

language = "English (US)",

volume = "161",

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journal = "Journal of Infectious Diseases",

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publisher = "Oxford University Press",

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AU - Ellner, Jerrold J.

AU - Wilson, Carla

AU - Toossi, Zahra

AU - El Kholy, Aziz

PY - 1990/6

Y1 - 1990/6

N2 - The immune response and its regulation by adherent mononuclear cells were investigated in 39 Egyptians aged 13-30 (mean ± SD, 16.2 ± 3.6) with chronic Schistosoma mansoni infection (fecal egg excretion, 40-2480 eggs/g; mean, 709 ± 612). Blastogenesis and production of interleukin-2 (IL-2) by peripheral blood mononuclear cells showed a significant correlation when streptolysin O but not when soluble worm antigenic preparation (SWAP) was used as stimulus. This suggested independent regulation of these responses to SWAP. Thirteen subjects showed SWAP-restricted suppression of blastogenesis but not IL-2 production by adherent cells. Compared with 24 other S. mansoni-infected subjects, they had depressed blastogenic responses to SWAP but comparable SWAP-induced IL-2 production and responsiveness to exogenous IL-2. This study indicates that IL-2 production is not the site of action of parasite antigen-restricted suppressor adherent cells in chronic S. mansoni infection.

AB - The immune response and its regulation by adherent mononuclear cells were investigated in 39 Egyptians aged 13-30 (mean ± SD, 16.2 ± 3.6) with chronic Schistosoma mansoni infection (fecal egg excretion, 40-2480 eggs/g; mean, 709 ± 612). Blastogenesis and production of interleukin-2 (IL-2) by peripheral blood mononuclear cells showed a significant correlation when streptolysin O but not when soluble worm antigenic preparation (SWAP) was used as stimulus. This suggested independent regulation of these responses to SWAP. Thirteen subjects showed SWAP-restricted suppression of blastogenesis but not IL-2 production by adherent cells. Compared with 24 other S. mansoni-infected subjects, they had depressed blastogenic responses to SWAP but comparable SWAP-induced IL-2 production and responsiveness to exogenous IL-2. This study indicates that IL-2 production is not the site of action of parasite antigen-restricted suppressor adherent cells in chronic S. mansoni infection.

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Regulation of antigen-induced blastogenesis and interleukin-2 expression by adherent mononuclear cells in humans infected with Schistosoma mansoni

Abstract

ASJC Scopus subject areas

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