Regulation and function of neurogenesis in the adult mammalian hypothalamus

Sooyeon Yoo, Seth Blackshaw

Research output: Contribution to journalReview articlepeer-review

Abstract

Over the past two decades, evidence has accumulated that neurogenesis can occur in both the juvenile and adult mammalian hypothalamus. Levels of hypothalamic neurogenesis can be regulated by dietary, environmental and hormonal signals. Since the hypothalamus has a central role in controlling a broad range of homeostatic physiological processes, these findings may have far ranging behavioral and medical implications. However, many questions in the field remain unresolved, including the cells of origin of newborn hypothalamic neurons and the extent to which these cells actually regulate hypothalamic-controlled behaviors. In this manuscript, we conduct a critical review of the literature on postnatal hypothalamic neurogenesis in mammals, lay out the main outstanding controversies in the field, and discuss how best to advance our knowledge of this fascinating but still poorly understood process.

Original languageEnglish (US)
Pages (from-to)53-66
Number of pages14
JournalProgress in Neurobiology
Volume170
DOIs
StatePublished - Nov 2018

Keywords

  • Aging
  • Ceproduction
  • Hypothalamus
  • Müller glia
  • Neurogenesis
  • Obesity
  • Plasticity
  • Progenitor
  • Sexual dimorphism
  • Stem cell
  • Tanycytes

ASJC Scopus subject areas

  • Neuroscience(all)

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