Regulation and characterization of the Na+/H+ exchanger

Larry Fliegel, Rakhilya Murtazina, Pavel Dibrov, Carmen Harris, Andrea Moor, Francoise A. Fernandez-Rachubinski

Research output: Contribution to journalArticle


The Na+/H+ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H+ for one extracellular Na+. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na+/H+ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity.

Original languageEnglish (US)
Pages (from-to)735-741
Number of pages7
JournalBiochemistry and Cell Biology
Issue number5
StatePublished - Dec 1 1998



  • Cation translocation
  • Intracellular pH
  • Membrane protein
  • Na/H antiporter
  • Protein phosphorylation
  • Protein-protein interaction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Fliegel, L., Murtazina, R., Dibrov, P., Harris, C., Moor, A., & Fernandez-Rachubinski, F. A. (1998). Regulation and characterization of the Na+/H+ exchanger. Biochemistry and Cell Biology, 76(5), 735-741.