Regulating telomere length from the inside out: The replication fork model

Research output: Contribution to journalArticlepeer-review

Abstract

Telomere length is regulated around an equilibrium set point. Telomeres shorten during replication and are lengthened by telomerase. Disruption of the length equilibrium leads to disease; thus, it is important to understand the mechanisms that regulate length at the molecular level. The prevailing protein-counting model for regulating telomerase access to elongate the telomere does not explain accumulating evidence of a role of DNA replication in telomere length regulation. Here I present an alternative model: the replication fork model that can explain how passage of a replication fork and regulation of origin firing affect telomere length.

Original languageEnglish (US)
Pages (from-to)1483-1491
Number of pages9
JournalGenes and Development
Volume30
Issue number13
DOIs
StatePublished - Jul 1 2016

Keywords

  • DNA replication
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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