Regulating supramolecular function in membranes: Calixarenes that enable or inhibit transmembrane Cl- transport

Jennifer L. Seganish, Paul V. Santacroce, Kevan J. Salimian, James C. Fettinger, Peter Zavalij, Jeffery T. Davis

Research output: Contribution to journalArticlepeer-review

Abstract

Self-assembled transporter: Self-association of a partial-cone calixarene amide provides membrane-active aggregates that enable the transport of chloride anions across phospholipid membranes (see picture). Additionally, a regulatory system is described, wherein an inactive calixarene analogue inhibits the active chloride transporter. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)3334-3338
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number20
DOIs
StatePublished - May 12 2006
Externally publishedYes

Keywords

  • Calixarenes
  • Ion channels
  • Ion transport
  • Self-assembly
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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