Regulating chemicals: Law, science, and the unbearable burdens of regulation

Ellen K. Silbergeld, Daniele Mandrioli, Carl F. Cranor

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


The challenges of regulating industrial chemicals remain unresolved in the United States. The Toxic Substances Control Act (TSCA) of 1976 was the first legislation to extend coverage to the regulation of industrial chemicals, both existing and newly registered. However, decisions related to both law and science that were made in passing this law inevitably rendered it ineffectual. Attempts to fix these shortcomings have not been successful. In light of the European Union's passage of innovative principles and requirements for chemical regulation, it is no longer possible to deny the opportunity and need for reform in US law and practice.

Original languageEnglish (US)
Pages (from-to)175-191
Number of pages17
JournalAnnual review of public health
StatePublished - Mar 18 2015


  • Burden of proof
  • TTIP
  • Toxic substances control act
  • Toxicology

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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