Regulated nucleosome mobility and the histone code

Michael S. Cosgrove, Jef D. Boeke, Cynthia Wolberger

Research output: Contribution to journalReview articlepeer-review

Abstract

Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.

Original languageEnglish (US)
Pages (from-to)1037-1043
Number of pages7
JournalNature Structural and Molecular Biology
Volume11
Issue number11
DOIs
StatePublished - Nov 1 2004

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Regulated nucleosome mobility and the histone code'. Together they form a unique fingerprint.

Cite this