Regressive phenomena: Refining connections

Will Agnew-Svoboda, Alex L Kolodkin, Martin M. Riccomagno

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Progressive events, such as the elaboration of axons and dendrites, create a template for the circuits that govern the many functions of our nervous system. As the nervous system develops, neurons are instructed through the extracellular milieu by guidance cues and form synaptic connections once they have reached their target region. Progressive events result not only in the creation of the proper circuitry, but also the formation of a number of supernumerary connections. In order for the nervous system to function properly, these connections must be removed through regressive events. Regressive events encompass a number of developmental processes, ranging from the removal of entire neurons and their processes, to restraining the development of microstructures at the level of the synapse. These processes often share a number of characteristics with programmed cell death. Furthermore, many of the guidance cues that instructed neurons to their target initially also regulate regressive events later in development. Beyond the removal of supernumerary connections, regressive processes also allow for the creation of a number of complex synaptic structures and the refinement of individual connections. Thus, the formation of a healthy and functional nervous system requires not only progressive events that establish initial neural connectivity, but also regressive events that further refine these neuronal circuits.

Original languageEnglish (US)
Title of host publicationNeuroscience in the 21st Century: From Basic to Clinical, Second Edition
PublisherSpringer New York
Pages265-294
Number of pages30
ISBN (Electronic)9781493934744
ISBN (Print)9781493934737
DOIs
StatePublished - Jan 1 2016

Fingerprint

refining
nervous system
Nervous System
neurons
Neurons
Cues
dendrites
synapse
Dendrites
axons
Synapses
microstructure
Axons
Cell Death
apoptosis

Keywords

  • Apoptosis
  • Axon degeneration
  • Axon retraction
  • Cell death
  • Complement cascade
  • Ephrins
  • Neuronal activity
  • Pruning
  • Semaphorins
  • Spine remodeling
  • Synapse elimination
  • Wallerian degeneration

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)

Cite this

Agnew-Svoboda, W., Kolodkin, A. L., & Riccomagno, M. M. (2016). Regressive phenomena: Refining connections. In Neuroscience in the 21st Century: From Basic to Clinical, Second Edition (pp. 265-294). Springer New York. https://doi.org/10.1007/978-1-4939-3474-4_132

Regressive phenomena : Refining connections. / Agnew-Svoboda, Will; Kolodkin, Alex L; Riccomagno, Martin M.

Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, 2016. p. 265-294.

Research output: Chapter in Book/Report/Conference proceedingChapter

Agnew-Svoboda, W, Kolodkin, AL & Riccomagno, MM 2016, Regressive phenomena: Refining connections. in Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, pp. 265-294. https://doi.org/10.1007/978-1-4939-3474-4_132
Agnew-Svoboda W, Kolodkin AL, Riccomagno MM. Regressive phenomena: Refining connections. In Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York. 2016. p. 265-294 https://doi.org/10.1007/978-1-4939-3474-4_132
Agnew-Svoboda, Will ; Kolodkin, Alex L ; Riccomagno, Martin M. / Regressive phenomena : Refining connections. Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, 2016. pp. 265-294
@inbook{35acf30840ed4c418cff3c276c47c4e8,
title = "Regressive phenomena: Refining connections",
abstract = "Progressive events, such as the elaboration of axons and dendrites, create a template for the circuits that govern the many functions of our nervous system. As the nervous system develops, neurons are instructed through the extracellular milieu by guidance cues and form synaptic connections once they have reached their target region. Progressive events result not only in the creation of the proper circuitry, but also the formation of a number of supernumerary connections. In order for the nervous system to function properly, these connections must be removed through regressive events. Regressive events encompass a number of developmental processes, ranging from the removal of entire neurons and their processes, to restraining the development of microstructures at the level of the synapse. These processes often share a number of characteristics with programmed cell death. Furthermore, many of the guidance cues that instructed neurons to their target initially also regulate regressive events later in development. Beyond the removal of supernumerary connections, regressive processes also allow for the creation of a number of complex synaptic structures and the refinement of individual connections. Thus, the formation of a healthy and functional nervous system requires not only progressive events that establish initial neural connectivity, but also regressive events that further refine these neuronal circuits.",
keywords = "Apoptosis, Axon degeneration, Axon retraction, Cell death, Complement cascade, Ephrins, Neuronal activity, Pruning, Semaphorins, Spine remodeling, Synapse elimination, Wallerian degeneration",
author = "Will Agnew-Svoboda and Kolodkin, {Alex L} and Riccomagno, {Martin M.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-3474-4_132",
language = "English (US)",
isbn = "9781493934737",
pages = "265--294",
booktitle = "Neuroscience in the 21st Century: From Basic to Clinical, Second Edition",
publisher = "Springer New York",

}

TY - CHAP

T1 - Regressive phenomena

T2 - Refining connections

AU - Agnew-Svoboda, Will

AU - Kolodkin, Alex L

AU - Riccomagno, Martin M.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Progressive events, such as the elaboration of axons and dendrites, create a template for the circuits that govern the many functions of our nervous system. As the nervous system develops, neurons are instructed through the extracellular milieu by guidance cues and form synaptic connections once they have reached their target region. Progressive events result not only in the creation of the proper circuitry, but also the formation of a number of supernumerary connections. In order for the nervous system to function properly, these connections must be removed through regressive events. Regressive events encompass a number of developmental processes, ranging from the removal of entire neurons and their processes, to restraining the development of microstructures at the level of the synapse. These processes often share a number of characteristics with programmed cell death. Furthermore, many of the guidance cues that instructed neurons to their target initially also regulate regressive events later in development. Beyond the removal of supernumerary connections, regressive processes also allow for the creation of a number of complex synaptic structures and the refinement of individual connections. Thus, the formation of a healthy and functional nervous system requires not only progressive events that establish initial neural connectivity, but also regressive events that further refine these neuronal circuits.

AB - Progressive events, such as the elaboration of axons and dendrites, create a template for the circuits that govern the many functions of our nervous system. As the nervous system develops, neurons are instructed through the extracellular milieu by guidance cues and form synaptic connections once they have reached their target region. Progressive events result not only in the creation of the proper circuitry, but also the formation of a number of supernumerary connections. In order for the nervous system to function properly, these connections must be removed through regressive events. Regressive events encompass a number of developmental processes, ranging from the removal of entire neurons and their processes, to restraining the development of microstructures at the level of the synapse. These processes often share a number of characteristics with programmed cell death. Furthermore, many of the guidance cues that instructed neurons to their target initially also regulate regressive events later in development. Beyond the removal of supernumerary connections, regressive processes also allow for the creation of a number of complex synaptic structures and the refinement of individual connections. Thus, the formation of a healthy and functional nervous system requires not only progressive events that establish initial neural connectivity, but also regressive events that further refine these neuronal circuits.

KW - Apoptosis

KW - Axon degeneration

KW - Axon retraction

KW - Cell death

KW - Complement cascade

KW - Ephrins

KW - Neuronal activity

KW - Pruning

KW - Semaphorins

KW - Spine remodeling

KW - Synapse elimination

KW - Wallerian degeneration

UR - http://www.scopus.com/inward/record.url?scp=85018904237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018904237&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-3474-4_132

DO - 10.1007/978-1-4939-3474-4_132

M3 - Chapter

AN - SCOPUS:85018904237

SN - 9781493934737

SP - 265

EP - 294

BT - Neuroscience in the 21st Century: From Basic to Clinical, Second Edition

PB - Springer New York

ER -