Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger

María C. Camilión De Hurtado, Enrique L. Portiansky, Néstor G. Pérez, Oscar R. Rebolledo, Horacio E. Cingolani

Research output: Contribution to journalArticle

Abstract

Objective: Experiments were performed to examine the effect of chronic inhibition of the Na+/H+ exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). Methods: SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). Results: The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of ∼6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28±0.05 to 3.04±0.05 (0.3 mg) and 2.99±0.10 (3.0 mg, P<0.05). Nifedipine, given for the same period, produced similar reduction in the hypertrophy index (3.03±0.05), but with a much greater decrease in arterial pressure (35.6±7.4 mmHg). Chronic treatment with cariporide induced a complete regression of the augmented cross sectional area of left ventricular myocytes without significant changes in collagen content, serum procollagen 1 propeptide levels or myocardial distensibility. Conclusions: NHE inhibition represents a novel approach to induce regression of pathological hypertrophy of the heart. The finding can be rationalized mechanistically by previous in vitro studies suggesting a role of the NHE in the development of myocardial hypertrophy.

Original languageEnglish (US)
Pages (from-to)862-868
Number of pages7
JournalCardiovascular research
Volume53
Issue number4
DOIs
StatePublished - Apr 9 2002

Keywords

  • Fibrosis
  • Hypertension
  • Hypertrophy
  • Ion exchangers
  • Na/H exchanger

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Camilión De Hurtado, M. C., Portiansky, E. L., Pérez, N. G., Rebolledo, O. R., & Cingolani, H. E. (2002). Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger. Cardiovascular research, 53(4), 862-868. https://doi.org/10.1016/S0008-6363(01)00544-2