Registration-based regional lung mechanical analysis: Retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition

Kai Ding, Kunlin Cao, Gary E. Christensen, Eric A. Hoffman, Joseph M. Reinhardt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The lungs undergo expansion and contraction during the respiratory cycle. Since many disease or injury conditions are associated with the biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation and regional mechanical changes. We describe a technique that uses multiple respiratory-gated CT images and non-rigid 3D image registration to make local estimates of lung tissue expansion. The degree of regional lung expansion is measured using the Jacobian (a function of local partial derivatives) of the registration displacement .eld. We compare the ventral-dorsal patterns of lung expansion estimated in both retrospectively reconstructed dynamic scans and static breath-hold scans to a xenon CT based measure of speci.c ventilation and a semi-automatic reference standard in four anesthetized sheep studied in the supine orientation. The regional lung expansion estimated by 3D image registration of images acquired at 50% and 75% phase points of the inspiratory portion of the respiratory cycle and 20 cm H2O and 25 cm H2O airway pressures gave the best match between the average Jacobian and the xenon CT speci.c ventilation respectively (linear regression, average r2 = 0.85 and r2 = 0.84). The registration accuracy assessed by 200 semi-automatically matched landmarks in both the dynamic and static scans show landmark error on the order of 2 mm.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - Jun 22 2009
Externally publishedYes
EventMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 10 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7262
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/8/092/10/09

Keywords

  • Functional imaging
  • Image registration
  • Pulmonary
  • Ventilation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Registration-based regional lung mechanical analysis: Retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition'. Together they form a unique fingerprint.

  • Cite this

    Ding, K., Cao, K., Christensen, G. E., Hoffman, E. A., & Reinhardt, J. M. (2009). Registration-based regional lung mechanical analysis: Retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition. In Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging [72620D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7262). https://doi.org/10.1117/12.813694