Registering molecular imaging information into anatomic images with improved spatial accuracy

Guarig Li, Huchen Xie, Holly Ning, Deborah Citrin, Jacek Capala, Roberto Maass-Moreno, Barbara C. Arora, C. Norman Coleman, Kevin Camphausen, Robert W. Miller

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To make molecular imaging useful in the clinic, accurate image registration must be done to correlate nano-scale events to macro-scale anatomy. The 3D volumetric image registration technique uses visual and quantitative measures to identify the most homogeneous color distribution on a volumetric anatomical landmark. Four phantom PET/CT images were acquired with 5.0±0.1 mm shift interval. The image registration shift was compared with the positioning shift. An accuracy of 0.1° and 0.1 mm was achieved. Cranial PET/CT images from 39 patients were examined. It was found that the average head motion was 0.5-1° and 1-3 mm, even with a stringent head holder. This small but significant misalignment is beyond the capability of conventional visual-based fusion methods used clinically. The 100 μm accuracy is a step forward to register molecular activities to anatomy for high precision interventions.

Original languageEnglish (US)
Title of host publication2007 4th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages1144-1147
Number of pages4
DOIs
StatePublished - Nov 27 2007
Event2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States
Duration: Apr 12 2007Apr 15 2007

Publication series

Name2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings

Other

Other2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
CountryUnited States
CityArlington, VA
Period4/12/074/15/07

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Medicine(all)

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  • Cite this

    Li, G., Xie, H., Ning, H., Citrin, D., Capala, J., Maass-Moreno, R., Arora, B. C., Coleman, C. N., Camphausen, K., & Miller, R. W. (2007). Registering molecular imaging information into anatomic images with improved spatial accuracy. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 1144-1147). [4193493] (2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings). https://doi.org/10.1109/ISBI.2007.357059