Registering molecular imaging information into anatomic images with improved spatial accuracy

Guarig Li; Huchen Xie; Holly Ning; Deborah Citrin; Jacek Capala; Roberto Maass-Moreno; Barbara C. Arora; C. Norman Coleman; Kevin Camphausen; Robert W. Miller

doi:10.1109/ISBI.2007.357059

Registering molecular imaging information into anatomic images with improved spatial accuracy

Guarig Li, Huchen Xie, Holly Ning, Deborah Citrin, Jacek Capala, Roberto Maass-Moreno, Barbara C. Arora, C. Norman Coleman, Kevin Camphausen, Robert W. Miller

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

To make molecular imaging useful in the clinic, accurate image registration must be done to correlate nano-scale events to macro-scale anatomy. The 3D volumetric image registration technique uses visual and quantitative measures to identify the most homogeneous color distribution on a volumetric anatomical landmark. Four phantom PET/CT images were acquired with 5.0±0.1 mm shift interval. The image registration shift was compared with the positioning shift. An accuracy of 0.1° and 0.1 mm was achieved. Cranial PET/CT images from 39 patients were examined. It was found that the average head motion was 0.5-1° and 1-3 mm, even with a stringent head holder. This small but significant misalignment is beyond the capability of conventional visual-based fusion methods used clinically. The 100 μm accuracy is a step forward to register molecular activities to anatomy for high precision interventions.

Original language	English (US)
Title of host publication	2007 4th IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	From Nano to Macro - Proceedings
Pages	1144-1147
Number of pages	4
DOIs	https://doi.org/10.1109/ISBI.2007.357059
State	Published - Nov 27 2007
Event	2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States Duration: Apr 12 2007 → Apr 15 2007

Publication series

Name	2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings

Other

Other	2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
Country/Territory	United States
City	Arlington, VA
Period	4/12/07 → 4/15/07

ASJC Scopus subject areas

Electrical and Electronic Engineering
Medicine(all)

Access to Document

10.1109/ISBI.2007.357059

Cite this

Li, G., Xie, H., Ning, H., Citrin, D., Capala, J., Maass-Moreno, R., Arora, B. C., Coleman, C. N., Camphausen, K., & Miller, R. W. (2007). Registering molecular imaging information into anatomic images with improved spatial accuracy. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 1144-1147). [4193493] (2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings). https://doi.org/10.1109/ISBI.2007.357059

Registering molecular imaging information into anatomic images with improved spatial accuracy. / Li, Guarig; Xie, Huchen; Ning, Holly et al.

2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. 2007. p. 1144-1147 4193493 (2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Li, G, Xie, H, Ning, H, Citrin, D, Capala, J, Maass-Moreno, R, Arora, BC, Coleman, CN, Camphausen, K & Miller, RW 2007, Registering molecular imaging information into anatomic images with improved spatial accuracy. in 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings., 4193493, 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings, pp. 1144-1147, 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07, Arlington, VA, United States, 4/12/07. https://doi.org/10.1109/ISBI.2007.357059

Li G, Xie H, Ning H, Citrin D, Capala J, Maass-Moreno R et al. Registering molecular imaging information into anatomic images with improved spatial accuracy. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. 2007. p. 1144-1147. 4193493. (2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings). doi: 10.1109/ISBI.2007.357059

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abstract = "To make molecular imaging useful in the clinic, accurate image registration must be done to correlate nano-scale events to macro-scale anatomy. The 3D volumetric image registration technique uses visual and quantitative measures to identify the most homogeneous color distribution on a volumetric anatomical landmark. Four phantom PET/CT images were acquired with 5.0±0.1 mm shift interval. The image registration shift was compared with the positioning shift. An accuracy of 0.1° and 0.1 mm was achieved. Cranial PET/CT images from 39 patients were examined. It was found that the average head motion was 0.5-1° and 1-3 mm, even with a stringent head holder. This small but significant misalignment is beyond the capability of conventional visual-based fusion methods used clinically. The 100 μm accuracy is a step forward to register molecular activities to anatomy for high precision interventions.",

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AU - Maass-Moreno, Roberto

AU - Arora, Barbara C.

AU - Coleman, C. Norman

AU - Camphausen, Kevin

AU - Miller, Robert W.

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N2 - To make molecular imaging useful in the clinic, accurate image registration must be done to correlate nano-scale events to macro-scale anatomy. The 3D volumetric image registration technique uses visual and quantitative measures to identify the most homogeneous color distribution on a volumetric anatomical landmark. Four phantom PET/CT images were acquired with 5.0±0.1 mm shift interval. The image registration shift was compared with the positioning shift. An accuracy of 0.1° and 0.1 mm was achieved. Cranial PET/CT images from 39 patients were examined. It was found that the average head motion was 0.5-1° and 1-3 mm, even with a stringent head holder. This small but significant misalignment is beyond the capability of conventional visual-based fusion methods used clinically. The 100 μm accuracy is a step forward to register molecular activities to anatomy for high precision interventions.

AB - To make molecular imaging useful in the clinic, accurate image registration must be done to correlate nano-scale events to macro-scale anatomy. The 3D volumetric image registration technique uses visual and quantitative measures to identify the most homogeneous color distribution on a volumetric anatomical landmark. Four phantom PET/CT images were acquired with 5.0±0.1 mm shift interval. The image registration shift was compared with the positioning shift. An accuracy of 0.1° and 0.1 mm was achieved. Cranial PET/CT images from 39 patients were examined. It was found that the average head motion was 0.5-1° and 1-3 mm, even with a stringent head holder. This small but significant misalignment is beyond the capability of conventional visual-based fusion methods used clinically. The 100 μm accuracy is a step forward to register molecular activities to anatomy for high precision interventions.

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Registering molecular imaging information into anatomic images with improved spatial accuracy

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