Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity

Madhumita Mandal, Deepak Kumar, Rajneeta Roy, Rupashree Sen, Padma Das, Mitali Chatterjee, Parasuraman Jaisankar

Research output: Contribution to journalArticle

Abstract

2,2′-Diphenyl-3,3′-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC50 of 13.0-17.0 μM.

Original languageEnglish (US)
Pages (from-to)3084-3087
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number10
DOIs
StatePublished - May 15 2011

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Keywords

  • Diindolyl ethylene
  • Friedel-Crafts acylation
  • In vitro cytotoxic activity
  • MTS-PMS assay
  • Nitroethane

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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