Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand

Peter G. Willis; Reeti Katoch-Rouse; Andrew G. Horti

doi:10.1002/jlcr.720

Regioselective F-18 radiolabeling of AM694, a CB₁ cannabinoid receptor ligand

Peter G. Willis, Reeti Katoch-Rouse, Andrew G. Horti

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

[¹⁸F]AM694, [1-(5-[ ¹⁸F]fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB ₁), has been synthesized by no-carrier-added regioselective radiofluorination of the corresponding tosylate. [¹⁸F]AM694 was obtained in 20% radiochemical yield (non-decay-corrected) with a specific activity of 14 500mCi/μmol, a radiochemical purity of >99%, and a chemical purity of 95.5%.

Original language	English (US)
Pages (from-to)	799-804
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	46
Issue number	9
DOIs	https://doi.org/10.1002/jlcr.720
State	Published - Aug 2003
Externally published	Yes

Keywords

AM694
Cannabinoid
F
Positron emission tomography
Radiotracer
Regioselective fluorination

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.720

Cite this

@article{0c100196454e46c39623c98d6d5e9e45,

title = "Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand",

abstract = "[18F]AM694, [1-(5-[ 18F]fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB 1), has been synthesized by no-carrier-added regioselective radiofluorination of the corresponding tosylate. [18F]AM694 was obtained in 20% radiochemical yield (non-decay-corrected) with a specific activity of 14 500mCi/μmol, a radiochemical purity of >99%, and a chemical purity of 95.5%.",

keywords = "AM694, Cannabinoid, F, Positron emission tomography, Radiotracer, Regioselective fluorination",

author = "Willis, {Peter G.} and Reeti Katoch-Rouse and Horti, {Andrew G.}",

year = "2003",

month = aug,

doi = "10.1002/jlcr.720",

language = "English (US)",

volume = "46",

pages = "799--804",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "9",

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T1 - Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand

AU - Willis, Peter G.

AU - Katoch-Rouse, Reeti

AU - Horti, Andrew G.

PY - 2003/8

Y1 - 2003/8

N2 - [18F]AM694, [1-(5-[ 18F]fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB 1), has been synthesized by no-carrier-added regioselective radiofluorination of the corresponding tosylate. [18F]AM694 was obtained in 20% radiochemical yield (non-decay-corrected) with a specific activity of 14 500mCi/μmol, a radiochemical purity of >99%, and a chemical purity of 95.5%.

AB - [18F]AM694, [1-(5-[ 18F]fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB 1), has been synthesized by no-carrier-added regioselective radiofluorination of the corresponding tosylate. [18F]AM694 was obtained in 20% radiochemical yield (non-decay-corrected) with a specific activity of 14 500mCi/μmol, a radiochemical purity of >99%, and a chemical purity of 95.5%.

KW - AM694

KW - Cannabinoid

KW - F

KW - Positron emission tomography

KW - Radiotracer

KW - Regioselective fluorination

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