Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand

Peter G. Willis, Reeti Katoch-Rouse, Andrew G. Horti

Research output: Contribution to journalArticle

Abstract

[18F]AM694, [1-(5-[ 18F]fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB 1), has been synthesized by no-carrier-added regioselective radiofluorination of the corresponding tosylate. [18F]AM694 was obtained in 20% radiochemical yield (non-decay-corrected) with a specific activity of 14 500mCi/μmol, a radiochemical purity of >99%, and a chemical purity of 95.5%.

Original languageEnglish (US)
Pages (from-to)799-804
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number9
DOIs
StatePublished - Aug 2003
Externally publishedYes

Keywords

  • AM694
  • Cannabinoid
  • F
  • Positron emission tomography
  • Radiotracer
  • Regioselective fluorination

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Regioselective F-18 radiolabeling of AM694, a CB<sub>1</sub> cannabinoid receptor ligand'. Together they form a unique fingerprint.

  • Cite this