Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand

Peter G. Willis, Reeti Katoch-Rouse, Andrew Horti

Research output: Contribution to journalArticle

Abstract

[18F]AM694, [1-(5-[ 18F]fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB 1), has been synthesized by no-carrier-added regioselective radiofluorination of the corresponding tosylate. [18F]AM694 was obtained in 20% radiochemical yield (non-decay-corrected) with a specific activity of 14 500mCi/μmol, a radiochemical purity of >99%, and a chemical purity of 95.5%.

Original languageEnglish (US)
Pages (from-to)799-804
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number9
DOIs
StatePublished - Aug 2003
Externally publishedYes

Fingerprint

Cannabinoid Receptor CB1
Cannabinoid Receptors
Ligands
Imaging techniques

Keywords

  • F
  • AM694
  • Cannabinoid
  • Positron emission tomography
  • Radiotracer
  • Regioselective fluorination

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Regioselective F-18 radiolabeling of AM694, a CB1 cannabinoid receptor ligand. / Willis, Peter G.; Katoch-Rouse, Reeti; Horti, Andrew.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, No. 9, 08.2003, p. 799-804.

Research output: Contribution to journalArticle

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