Regional wall motion and strain of transplanted hearts in pediatric patients using magnetic resonance tagging

Mary T. Donofrio, Bernard J. Clark, Claudio Ramaciotti, Marshall L. Jacobs, Kenneth E. Fellows, Paul M. Weinberg, Mark A. Fogel

Research output: Contribution to journalArticlepeer-review

Abstract

Abnormal ventricular systolic torsion is present during histological rejection in adult cardiac transplant patients. Because biomechanical properties of transplanted hearts in the baseline state have not been studied in children, pediatric patients were evaluated to quantify ventricular wall motion and strain. Eight transplant studies and eight normal controls were evaluated. Magnetic resonance tagging was performed to determine radial shortening, twist, and strain in four ventricular anatomic areas at two short-axis levels. Controls had counterclockwise twist. Six transplant studies had clockwise twist, six had akinetic regions, and all had regions of no twist. One demonstrated paradoxical motion of the septum. A comparison between transplant patients and controls revealed strain to be similar in all regions except one (superior wall at the atrioventricular valve level) and strain distribution to be different only in two of eight regions. Pediatric transplant patients demonstrate regional wall motion abnormalities in the absence of rejection. Compared with normal controls, the transplanted left ventricle maintains normal strain in the presence of abnormal twist. This may be a compensatory mechanism and have clinical implications.

Original languageEnglish (US)
Pages (from-to)R1481-R1487
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number5 46-5
StatePublished - Nov 1 1999
Externally publishedYes

Keywords

  • Magnetic resonance imaging
  • Pediatric orthotopic cardiac transplant
  • Spatial modulation of magnetization

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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