TY - JOUR
T1 - Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi
AU - Martin, Diana L.
AU - Marks, Morgan
AU - Galdos-Cardenas, Gerson
AU - Gilman, Robert H.
AU - Goodhew, Brook
AU - Ferrufino, Lisbeth
AU - Halperin, Anthony
AU - Sanchez, Gerardo
AU - Verastegui, Manuela
AU - Escalante, Patricia
AU - Naquira, Cesar
AU - Levy, Michael Z.
AU - Bern, Caryn
PY - 2014/6
Y1 - 2014/6
N2 - Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-γ (IFNγ)-secreting cells from Peruvian samples. However, the magnitude of the IFNγ response was similar among the IFNγ responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.
AB - Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-γ (IFNγ)-secreting cells from Peruvian samples. However, the magnitude of the IFNγ response was similar among the IFNγ responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.
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U2 - 10.4269/ajtmh.13-0391
DO - 10.4269/ajtmh.13-0391
M3 - Article
C2 - 24710614
AN - SCOPUS:84902264661
SN - 0002-9637
VL - 90
SP - 1074
EP - 1081
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 6
ER -