Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi

Diana L. Martin, Morgan Marks, Gerson Galdos-Cardenas, Robert H. Gilman, Brook Goodhew, Lisbeth Ferrufino, Anthony Halperin, Gerardo Sanchez, Manuela Verastegui, Patricia Escalante, Cesar Naquira, Michael Z. Levy, Caryn Bern

Research output: Contribution to journalArticlepeer-review

Abstract

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-γ (IFNγ)-secreting cells from Peruvian samples. However, the magnitude of the IFNγ response was similar among the IFNγ responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.

Original languageEnglish (US)
Pages (from-to)1074-1081
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume90
Issue number6
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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