Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)

M. V. Downer; T. Hodge; D. K. Smith; S. H. Qari; P. Schuman; K. H. Mayer; R. S. Klein; D. Vlahov; L. I. Gardner; J. M. McNicholl

doi:10.1038/sj.gene.6363884

Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)

M. V. Downer, T. Hodge, D. K. Smith, S. H. Qari, P. Schuman, K. H. Mayer, R. S. Klein, D. Vlahov, L. I. Gardner, J. M. McNicholl

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The CCR5-Δ32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5-Δ32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3. 1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.

Original language	English (US)
Pages (from-to)	295-298
Number of pages	4
Journal	Genes and immunity
Volume	3
Issue number	5
DOIs	https://doi.org/10.1038/sj.gene.6363884
State	Published - Aug 2002
Externally published	Yes

Keywords

Black/African American
Chemokine receptor
HIV-1 infection
Regional difference

ASJC Scopus subject areas

Immunology
Genetics
Genetics(clinical)

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10.1038/sj.gene.6363884

Cite this

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title = "Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)",

abstract = "The CCR5-Δ32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5-Δ32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3. 1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.",

keywords = "Black/African American, Chemokine receptor, HIV-1 infection, Regional difference",

author = "Downer, {M. V.} and T. Hodge and Smith, {D. K.} and Qari, {S. H.} and P. Schuman and Mayer, {K. H.} and Klein, {R. S.} and D. Vlahov and Gardner, {L. I.} and McNicholl, {J. M.}",

note = "Funding Information: MVD was supported by a CDC/ATPM Career Development Award Fellowship. Received 26 October 2001; revised 1 March 2002; accepted 5 May 2002",

year = "2002",

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doi = "10.1038/sj.gene.6363884",

language = "English (US)",

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journal = "Genes and immunity",

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AU - Downer, M. V.

AU - Hodge, T.

AU - Smith, D. K.

AU - Qari, S. H.

AU - Schuman, P.

AU - Mayer, K. H.

AU - Klein, R. S.

AU - Vlahov, D.

AU - Gardner, L. I.

AU - McNicholl, J. M.

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N2 - The CCR5-Δ32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5-Δ32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3. 1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.

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KW - Regional difference

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Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)

Abstract

Keywords

ASJC Scopus subject areas

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