Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)

M. V. Downer, T. Hodge, D. K. Smith, S. H. Qari, P. Schuman, K. H. Mayer, R. S. Klein, D. Vlahov, L. I. Gardner, J. M. McNicholl

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The CCR5-Δ32 genotype is known to influence HIV-1 transmission and disease. We genotyped 1301 US women of various races/ethnicities participating in the HIV Epidemiologic Research Study. None was homozygous for CCR5-Δ32. The distribution of heterozygotes was similar in HIV-1 infected and uninfected women. Thirty-seven (11.8%) white, 28 (3.7%) blacks/African Americans (AA), seven (3.3%) Hispanics/Latinas, and one (6.6%) other race/ethnicity were heterozygous. The frequency of heterozygotes differed among sites for all races combined (P = 0.001). More heterozygotes were found in AA women in Rhode Island (8.9%) than in the other sites (3. 1%) (P = 0.02), while heterozygosity in white women was most common in Maryland (28.6%) (P = 0.025). These regional differences could be accounted for by racial admixture in AAs, but not in whites. Regional variations should be considered when studying host genetic factors and HIV-1 in US populations.

    Original languageEnglish (US)
    Pages (from-to)295-298
    Number of pages4
    JournalGenes and immunity
    Volume3
    Issue number5
    DOIs
    StatePublished - Aug 2002

    Keywords

    • Black/African American
    • Chemokine receptor
    • HIV-1 infection
    • Regional difference

    ASJC Scopus subject areas

    • Immunology
    • Genetics
    • Genetics(clinical)

    Fingerprint

    Dive into the research topics of 'Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)'. Together they form a unique fingerprint.

    Cite this