Regional myocardial blood flow in the dog studied with radioactive microspheres

Nicholas J. Fortuin, Shigekoto Kaihara, Lewis Becker, Bertram Pitt

Research output: Contribution to journalArticle


Authors' synopsis: Regional myocardial blood flow was studied in the anaesthetized dog by determining the distribution of 15 and 50μ radioactive microspheres after left atrial injection. Doses of the 15μ spheres below 4 × 106 did not significantly alter coronary or systemic haemodynamics. Larger doses produced a significant increase in mean aortic pressure. Less than 1% of the 15μ spheres delivered to the heart passed into the coronary sinus. The myocardial distribution of 15 and 50μ spheres was not significantly different except for the ratio of left ventricular endocardium to epicardium (1·12 for 15μ and 1·45 for 50μ, P<0.001). Using 15μ spheres, it was found that the ratio of endocardial to epicardial radioactivity in the left ventricular wall was increased by propranolol, decreased by isoprenaline, and unchanged by nitroglycerin.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalCardiovascular Research
Issue number3
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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