Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium

Paul A. Harris, Christine H. Lorenz, George E. Holburn, Knowles A. Overholser

Research output: Contribution to journalArticlepeer-review


Quantifiable MRI perfusion studies using the contrast agent Gd-DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radio-tracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short-axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.

Original languageEnglish (US)
Pages (from-to)541-545
Number of pages5
JournalMagnetic Resonance in Medicine
Issue number4
StatePublished - Oct 1997
Externally publishedYes


  • Gd-DTPA
  • Myocardium
  • Partition coefficient
  • Tracer kinetic modeling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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