Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium

Paul A. Harris, Christine H. Lorenz, George E. Holburn, Knowles A. Overholser

Research output: Contribution to journalArticle

Abstract

Quantifiable MRI perfusion studies using the contrast agent Gd-DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radio-tracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short-axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.

Original languageEnglish (US)
Pages (from-to)541-545
Number of pages5
JournalMagnetic Resonance in Medicine
Volume38
Issue number4
DOIs
StatePublished - Oct 1997
Externally publishedYes

Fingerprint

Gadolinium DTPA
Canidae
Myocardium
Plasma Volume
Radio
Hematocrit
Contrast Media
Heart Ventricles
Perfusion
Dogs

Keywords

  • Gd-DTPA
  • Myocardium
  • Partition coefficient
  • Tracer kinetic modeling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium. / Harris, Paul A.; Lorenz, Christine H.; Holburn, George E.; Overholser, Knowles A.

In: Magnetic Resonance in Medicine, Vol. 38, No. 4, 10.1997, p. 541-545.

Research output: Contribution to journalArticle

Harris, Paul A. ; Lorenz, Christine H. ; Holburn, George E. ; Overholser, Knowles A. / Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium. In: Magnetic Resonance in Medicine. 1997 ; Vol. 38, No. 4. pp. 541-545.
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