Abstract
Quantifiable MRI perfusion studies using the contrast agent Gd-DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radio-tracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short-axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.
Original language | English (US) |
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Pages (from-to) | 541-545 |
Number of pages | 5 |
Journal | Magnetic Resonance in Medicine |
Volume | 38 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1997 |
Externally published | Yes |
Keywords
- Gd-DTPA
- Myocardium
- Partition coefficient
- Tracer kinetic modeling
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology