Abstract
Quantifiable MRI perfusion studies using the contrast agent Gd-DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radio-tracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short-axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 541-545 |
| Number of pages | 5 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1997 |
| Externally published | Yes |
Keywords
- Gd-DTPA
- Myocardium
- Partition coefficient
- Tracer kinetic modeling
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
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Harris, P. A., Lorenz, C. H., Holburn, G. E., & Overholser, K. A. (1997). Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium. Magnetic Resonance in Medicine, 38(4), 541-545. https://doi.org/10.1002/mrm.1910380406