Abstract
Quantifiable MRI perfusion studies using the contrast agent Gd-DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radio-tracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short-axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 541-545 |
| Number of pages | 5 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1997 |
| Externally published | Yes |
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Keywords
- Gd-DTPA
- Myocardium
- Partition coefficient
- Tracer kinetic modeling
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium. / Harris, Paul A.; Lorenz, Christine H.; Holburn, George E.; Overholser, Knowles A.
In: Magnetic Resonance in Medicine, Vol. 38, No. 4, 10.1997, p. 541-545.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional measurement of the Gd-DTPA tissue partition coefficient in canine myocardium
AU - Harris, Paul A.
AU - Lorenz, Christine H.
AU - Holburn, George E.
AU - Overholser, Knowles A.
PY - 1997/10
Y1 - 1997/10
N2 - Quantifiable MRI perfusion studies using the contrast agent Gd-DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radio-tracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short-axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.
AB - Quantifiable MRI perfusion studies using the contrast agent Gd-DTPA require measurement or estimation of the tissue partition coefficient (λ) for tracer kinetic modeling. Radio-tracer techniques were used to obtain regional λ measurements from the left ventricles of five dogs. Measurements were analyzed to determine whether spatial heterogeneity was a major component of λ variability. No systematic variations were identified in terms of radial position, short-axis slice location, or wall position. The high λ variability seen in this study and in cited data of others may be due in part to tissue heterogeneity in interstitial volume, plasma volume, and perfusate hematocrit.
KW - Gd-DTPA
KW - Myocardium
KW - Partition coefficient
KW - Tracer kinetic modeling
UR - http://www.scopus.com/inward/record.url?scp=0030983844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030983844&partnerID=8YFLogxK
U2 - 10.1002/mrm.1910380406
DO - 10.1002/mrm.1910380406
M3 - Article
C2 - 9324319
AN - SCOPUS:0030983844
VL - 38
SP - 541
EP - 545
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 4
ER -