Regional localization of the autosomal dominant polycystic kidney disease locus

S. T. Reeders, T. Keith, P. Green, G. G. Germino, N. J. Barton, O. J. Lehmann, V. A. Brown, P. Phipps, J. Morgan, J. C. Bear, P. Parfrey

Research output: Contribution to journalArticlepeer-review

Abstract

The localization of the autosomal dominant polycystic kidney disease locus (PKD1) within an array of anonymous polymorphic DNA sequences on chromosome 16 band p13 was determined by multipoint mapping. Nine polymorphic DNA markers, including two hypervariable sequences, were used to study 19 PKD1 and 21 reference families. PKD1 was found to lie proximal to the 3′ and 5′ hypervariable regions of α-globin and distal to the anonymous sequence CRI-0327. Somatic cell hybrid mapping places PKD1 within the region 16p13.11-16pter. The availability of an array of linked markers which bracket the PKD1 locus provides a framework for further attempts to identify the PKD1 gene and offers an improved method of presymptomatic diagnosis of the disease.

Original languageEnglish (US)
Pages (from-to)150-155
Number of pages6
JournalGenomics
Volume3
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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