Regional localization of the autosomal dominant polycystic kidney disease locus

S. T. Reeders; T. Keith; P. Green; G. G. Germino; N. J. Barton; O. J. Lehmann; V. A. Brown; P. Phipps; J. Morgan; J. C. Bear; P. Parfrey

doi:10.1016/0888-7543(88)90146-2

Regional localization of the autosomal dominant polycystic kidney disease locus

S. T. Reeders, T. Keith, P. Green, G. G. Germino, N. J. Barton, O. J. Lehmann, V. A. Brown, P. Phipps, J. Morgan, J. C. Bear, P. Parfrey

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The localization of the autosomal dominant polycystic kidney disease locus (PKD1) within an array of anonymous polymorphic DNA sequences on chromosome 16 band p13 was determined by multipoint mapping. Nine polymorphic DNA markers, including two hypervariable sequences, were used to study 19 PKD1 and 21 reference families. PKD1 was found to lie proximal to the 3′ and 5′ hypervariable regions of α-globin and distal to the anonymous sequence CRI-0327. Somatic cell hybrid mapping places PKD1 within the region 16p13.11-16pter. The availability of an array of linked markers which bracket the PKD1 locus provides a framework for further attempts to identify the PKD1 gene and offers an improved method of presymptomatic diagnosis of the disease.

Original language	English (US)
Pages (from-to)	150-155
Number of pages	6
Journal	Genomics
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(88)90146-2
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/0888-7543(88)90146-2

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title = "Regional localization of the autosomal dominant polycystic kidney disease locus",

abstract = "The localization of the autosomal dominant polycystic kidney disease locus (PKD1) within an array of anonymous polymorphic DNA sequences on chromosome 16 band p13 was determined by multipoint mapping. Nine polymorphic DNA markers, including two hypervariable sequences, were used to study 19 PKD1 and 21 reference families. PKD1 was found to lie proximal to the 3′ and 5′ hypervariable regions of α-globin and distal to the anonymous sequence CRI-0327. Somatic cell hybrid mapping places PKD1 within the region 16p13.11-16pter. The availability of an array of linked markers which bracket the PKD1 locus provides a framework for further attempts to identify the PKD1 gene and offers an improved method of presymptomatic diagnosis of the disease.",

author = "Reeders, {S. T.} and T. Keith and P. Green and Germino, {G. G.} and Barton, {N. J.} and Lehmann, {O. J.} and Brown, {V. A.} and P. Phipps and J. Morgan and Bear, {J. C.} and P. Parfrey",

year = "1988",

doi = "10.1016/0888-7543(88)90146-2",

language = "English (US)",

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pages = "150--155",

journal = "Genomics",

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publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Regional localization of the autosomal dominant polycystic kidney disease locus

AU - Reeders, S. T.

AU - Keith, T.

AU - Green, P.

AU - Germino, G. G.

AU - Barton, N. J.

AU - Lehmann, O. J.

AU - Brown, V. A.

AU - Phipps, P.

AU - Morgan, J.

AU - Bear, J. C.

AU - Parfrey, P.

PY - 1988

Y1 - 1988

N2 - The localization of the autosomal dominant polycystic kidney disease locus (PKD1) within an array of anonymous polymorphic DNA sequences on chromosome 16 band p13 was determined by multipoint mapping. Nine polymorphic DNA markers, including two hypervariable sequences, were used to study 19 PKD1 and 21 reference families. PKD1 was found to lie proximal to the 3′ and 5′ hypervariable regions of α-globin and distal to the anonymous sequence CRI-0327. Somatic cell hybrid mapping places PKD1 within the region 16p13.11-16pter. The availability of an array of linked markers which bracket the PKD1 locus provides a framework for further attempts to identify the PKD1 gene and offers an improved method of presymptomatic diagnosis of the disease.

AB - The localization of the autosomal dominant polycystic kidney disease locus (PKD1) within an array of anonymous polymorphic DNA sequences on chromosome 16 band p13 was determined by multipoint mapping. Nine polymorphic DNA markers, including two hypervariable sequences, were used to study 19 PKD1 and 21 reference families. PKD1 was found to lie proximal to the 3′ and 5′ hypervariable regions of α-globin and distal to the anonymous sequence CRI-0327. Somatic cell hybrid mapping places PKD1 within the region 16p13.11-16pter. The availability of an array of linked markers which bracket the PKD1 locus provides a framework for further attempts to identify the PKD1 gene and offers an improved method of presymptomatic diagnosis of the disease.

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JO - Genomics

JF - Genomics

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Regional localization of the autosomal dominant polycystic kidney disease locus

Abstract

ASJC Scopus subject areas

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