Regional left ventricular myocardial dysfunction as a predictor of incident cardiovascular events: MESA (Multi-Ethnic Study of Atherosclerosis)

Raymond T. Yan, David Bluemke, Antoinette Gomes, Gregory Burke, Steve Shea, Kiang Liu, Hossein Bahrami, Shantanu Sinha, Colin Wu, Veronica Fernandes, Robyn McClelland, Joao Lima

Research output: Contribution to journalArticle

Abstract

Objectives: We sought to examine the prognostic value of subclinical left ventricular (LV) regional myocardial dysfunction (RMD) measured by magnetic resonance imaging (MRI) among asymptomatic individuals. Background: LV RMD, defined as segmental impairment in systolic wall thickening, predicts adverse events in patients with established cardiovascular disease. MRI is highly accurate for detecting subtle RMD, of which the prognostic significance in a large multiethnic asymptomatic population is not known. Methods: We used MRI to evaluate baseline regional LV myocardial function and prospectively followed a multiethnic (African American, Caucasian, Chinese, and Hispanic) population-based sample of 4,510 men and women without cardiovascular disease for a mean of 4.6 years. Regional myocardial dysfunction was defined as the presence of impaired systolic wall thickening (

Original languageEnglish (US)
Pages (from-to)1735-1744
Number of pages10
JournalJournal of the American College of Cardiology
Volume57
Issue number17
DOIs
StatePublished - Apr 26 2011

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Left Ventricular Dysfunction
Atherosclerosis
Magnetic Resonance Imaging
Cardiovascular Diseases
Left Ventricular Function
Hispanic Americans
African Americans
Population

Keywords

  • epidemiology
  • heart failure
  • magnetic resonance imaging
  • myocardial dysfunction
  • prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Regional left ventricular myocardial dysfunction as a predictor of incident cardiovascular events : MESA (Multi-Ethnic Study of Atherosclerosis). / Yan, Raymond T.; Bluemke, David; Gomes, Antoinette; Burke, Gregory; Shea, Steve; Liu, Kiang; Bahrami, Hossein; Sinha, Shantanu; Wu, Colin; Fernandes, Veronica; McClelland, Robyn; Lima, Joao.

In: Journal of the American College of Cardiology, Vol. 57, No. 17, 26.04.2011, p. 1735-1744.

Research output: Contribution to journalArticle

Yan, Raymond T. ; Bluemke, David ; Gomes, Antoinette ; Burke, Gregory ; Shea, Steve ; Liu, Kiang ; Bahrami, Hossein ; Sinha, Shantanu ; Wu, Colin ; Fernandes, Veronica ; McClelland, Robyn ; Lima, Joao. / Regional left ventricular myocardial dysfunction as a predictor of incident cardiovascular events : MESA (Multi-Ethnic Study of Atherosclerosis). In: Journal of the American College of Cardiology. 2011 ; Vol. 57, No. 17. pp. 1735-1744.
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AU - Burke, Gregory

AU - Shea, Steve

AU - Liu, Kiang

AU - Bahrami, Hossein

AU - Sinha, Shantanu

AU - Wu, Colin

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