Regional glucose phosphorylation rate in rat brain during acute ethanol intoxication

H. E. Brøndsted; J. Reith; A. Gjedde

doi:10.1111/j.1600-0404.1990.tb00971.x

Regional glucose phosphorylation rate in rat brain during acute ethanol intoxication

H. E. Brøndsted, J. Reith, A. Gjedde

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effect of ethanol on regional cerebral metabolic rate for glucose (rCMRglc) was studied in rats using [6‐¹⁴C]glucose. After intravenous injection, radioactivity was determined in 14 brain regions, corrected for loss of label, and divided by the integral of the arterial plasma glucose concentration measured during tracer circulation. When blood ethanol concentration was maintained at 6 g/l by intravenous infusion of ethanol for approximately 1 h, rCMRglc was found to be reduced significantly in 7 forebrain regions, compared to values of conscious control animals. In 7 further regions including brain stem regions, rCMRglc was not significantly reduced. We conclude that the effects of severe acute alcohol intoxication resemble those of global anesthesia.

Original language	English (US)
Pages (from-to)	229-231
Number of pages	3
Journal	Acta Neurologica Scandinavica
Volume	81
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0404.1990.tb00971.x
State	Published - Mar 1990
Externally published	Yes

Keywords

alcohol
brain metabolism
ethanol intoxication
glucose phosphorylation
rat brain

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1600-0404.1990.tb00971.x

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AU - Reith, J.

AU - Gjedde, A.

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AB - The effect of ethanol on regional cerebral metabolic rate for glucose (rCMRglc) was studied in rats using [6‐14C]glucose. After intravenous injection, radioactivity was determined in 14 brain regions, corrected for loss of label, and divided by the integral of the arterial plasma glucose concentration measured during tracer circulation. When blood ethanol concentration was maintained at 6 g/l by intravenous infusion of ethanol for approximately 1 h, rCMRglc was found to be reduced significantly in 7 forebrain regions, compared to values of conscious control animals. In 7 further regions including brain stem regions, rCMRglc was not significantly reduced. We conclude that the effects of severe acute alcohol intoxication resemble those of global anesthesia.

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Regional glucose phosphorylation rate in rat brain during acute ethanol intoxication

Abstract

Keywords

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