Regional Differences in the Structure of the Lamina Cribrosa and Their Relation to Glaucomatous Optic Nerve Damage

Harry A Quigley, Earl M. Addicks

Research output: Contribution to journalArticle

Abstract

Previously, there was no feature of optic nerve head anatomy or physiology that could explain the greater susceptibility for early damage in some nerve fibers by chronic glaucoma. Using a new technique for scanning electron microscopic examination of human optic nerve heads, regional differences were found in the fine structure of the lamina cribrosa. The superior and inferior parts of the lamina at the level of the sclera appear to contain larger pores and thinner connective tissue support for the passage of nerve-fiber bundles than the nasal and temporal parts of the lamina. Since the superior and inferior laminar zones are the sites of passage for arcuate area ganglion cell axons that are most susceptible to glaucoma damage, the differences found in laminar structure in these locations may explain the characteristic pattern of early glaucomatous field loss.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalArchives of Ophthalmology
Volume99
Issue number1
DOIs
StatePublished - 1981

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Optic Disk
Optic Nerve
Nerve Fibers
Glaucoma
Sclera
Nose
Ganglia
Connective Tissue
Axons
Anatomy
Electrons

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Regional Differences in the Structure of the Lamina Cribrosa and Their Relation to Glaucomatous Optic Nerve Damage. / Quigley, Harry A; Addicks, Earl M.

In: Archives of Ophthalmology, Vol. 99, No. 1, 1981, p. 137-143.

Research output: Contribution to journalArticle

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