Regional differences in shape and load in normal and diseased hearts studied by three dimensional tagged magnetic resonance imaging

Yael Fisher Petrank, Sheng Jing Dong, John Tyberg, Samuel Sideman, Rafael Beyar

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We aimed to characterize regional geometry in relation to load in two groups of patients with hypertrophic cardiomyopathy (HCM) and right ventricular pressure overload (RVPO) in relation to a group of subjects with normal left ventricular (LV) function. Background: Both these diseases are associated with marked changes in LV shape and function, which have not been studied with detailed three dimensional tools. Methods: Three dimensional (3D) tagged magnetic resonance imaging (MRI) was used to characterize the 3D geometry and regional stresses of the left ventricles in patients with HCM and RVPO. Curvatures, stresses, wall thickness, and endocardial motion were calculated from surface and volume elements. Results: Hearts with RVPO exhibited more circumferential and meridional flattening of the septum than normal and HCM hearts The stress indices were lowest in the HCM hearts, compared to normal and RVPO hearts, due to the larger thicknesses. There was a more significant difference between lateral wall motion and other regional wall motions in the HCM and RVPO hearts as compared to normal hearts. Conclusions: It is suggested that curvature and stress mapping by 3D tagged MRI can be used as an important clinical tool for characterizing and distinguishing between healthy and diseased hearts. The results provided here validated previous knowledge on HCM and RVPO known from planary imaging methods.

Original languageEnglish (US)
Pages (from-to)309-321
Number of pages13
JournalInternational Journal of Cardiovascular Imaging
Volume15
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Curvature
  • Heart
  • Hypertrophic cardiomyopathy
  • Regional load
  • Right ventricular pressure overload

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Regional differences in shape and load in normal and diseased hearts studied by three dimensional tagged magnetic resonance imaging'. Together they form a unique fingerprint.

Cite this