Regional differences in diffusion tensor imaging measurements: Assessment of intrarater and interrater variability

A. Ozturk, A. D. Sasson, J. A D Farrell, B. A. Landman, A. C B S Da Motta, A. Aralasmak, David Mark Yousem

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) has become a valuable tool in both the research and clinical evaluation of subjects. We sought to quantify interobserver and intraobserver variability of diffusivity and diffusion anisotropy measurements with regard to specific regions of interest (ROIs). MATERIALS AND METHODS: The subject group consisted of 5 healthy control subjects and 7 study subjects (all males; 16-19 years old; mean age = 17.5 years), as part of a protocol for closed head injury. Two whole-brain DTI scans were acquired on a 3T scanner for each subject. Analysis was performed using a ROI approach. Two independent observers analyzed the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) indices in the corpus callosum, cortical spinal tract, internal capsules (ICs), basal ganglia, and centrum semiovale (CSO). Intraobserver and interobserver variability were calculated for the mean ADC, FA, and ordered eigenvalues of the diffusion tensor (λ1, λ2, and λ3). RESULTS: The overall κ statistic for intraobserver variability for both observers showed slight-to-substantial agreement (κ = 0.02-0.69), however FA values in the CSO showed only slight agreement. Interobserver agreement was also slight to substantial for these DTI measurements with high variability in FA values in the IC and CSO. CONCLUSIONS: When one is comparing 2 DTI measurements, it is important to assess intraobserver and interobserver variability. We recommend caution in the analysis of DTI contrasts in the IC and CSO, because we have found the widest range of variability in measurements within these structures.

Original languageEnglish (US)
Pages (from-to)1124-1127
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume29
Issue number6
DOIs
StatePublished - Jun 2008

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Diffusion Tensor Imaging
Anisotropy
Observer Variation
Internal Capsule
Closed Head Injuries
Corpus Callosum
Basal Ganglia
Healthy Volunteers
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

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Regional differences in diffusion tensor imaging measurements : Assessment of intrarater and interrater variability. / Ozturk, A.; Sasson, A. D.; Farrell, J. A D; Landman, B. A.; Da Motta, A. C B S; Aralasmak, A.; Yousem, David Mark.

In: American Journal of Neuroradiology, Vol. 29, No. 6, 06.2008, p. 1124-1127.

Research output: Contribution to journalArticle

Ozturk, A. ; Sasson, A. D. ; Farrell, J. A D ; Landman, B. A. ; Da Motta, A. C B S ; Aralasmak, A. ; Yousem, David Mark. / Regional differences in diffusion tensor imaging measurements : Assessment of intrarater and interrater variability. In: American Journal of Neuroradiology. 2008 ; Vol. 29, No. 6. pp. 1124-1127.
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