Regional deposition of inhaled fog droplets

Preliminary observations

S. M. Bowes, Beth L Laube, Jonathan M Links, R. Frank

Research output: Contribution to journalArticle

Abstract

The regional deposition of a monodisperse 10-μm mass median aerodynamic diameter fog was studied in four healthy adult male nonsmokers. The fog was radiolabeled with technetium-99m sulfur colloid to enable detection by an Anger camera of deposited activity in the following regions of the respiratory tract: oropharynx, larynx, trachea, and intrapulmonary airways. Intrapulmonary deposition was further analyzed by computer with inner, intermediate, and outer zones, and within apical, intermediate and basal zones of the right lung. The radiolabeled aerosol was inhaled by mouth through a face-mask with the nasal airway occluded. Respiratory frequency, tidal volume, and jaw position were controlled and were commensurate with the oral component of oronasal breathing during moderate exercise. Deposition in the larynx, trachea, and intrapulmonary airways was a function of the scrubbing efficiency of the oropharynx, which differed substantially among subjects, and ranged from 72 to 99%. The density of the aerosol deposit in the larynx probably exceeded that of any of the subdivisions of the tracheobronchial tree and lung. Within the lung, deposition favored the inner zone (assumed to contain the larger airways) over the outer zone (assumed to be dominated by smaller airways and alveoli). Intrapulmonary aerosol distribution in an elderly subject with borderline evidence of airway obstruction differed from that observed in younger subjects. The possible consequences of altered lung elastic recoil, as may occur with aging, for regional dosimetry is discussed.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalEnvironmental Health Perspectives
Volume79
StatePublished - 1989

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Weather
Fog
fog
droplet
Larynx
Aerosols
Lung
Oropharynx
aerosol
Trachea
Technetium Tc 99m Sulfur Colloid
technetium
Technetium
Tidal Volume
Anger
Airway Obstruction
Masks
colloid
Jaw
Nose

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Regional deposition of inhaled fog droplets : Preliminary observations. / Bowes, S. M.; Laube, Beth L; Links, Jonathan M; Frank, R.

In: Environmental Health Perspectives, Vol. 79, 1989, p. 151-157.

Research output: Contribution to journalArticle

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