Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI

Jean François Payen, Emmanuel Briot, Irène Tropres, Cécile Julien-Dolbec, Olivier Montigon, Michel Decorps

Research output: Contribution to journalArticle

Abstract

We used steady-state susceptibility contrast MRI to evaluate the regional cerebral blood volume (rCBV) response to hypocapnia in anesthetised rats. The rCBV was determined in the dorsoparietal neocortex, the corpus striatum, the cerebellum, as well as blood volume in extracerebral tissue (group 1). In addition, we used laser-Doppler flow (LDF) measurements in the left dorsoparietal neocortex (group 2), to correlate changes in CBV and in cerebral blood flow. Baseline values, expressed as a percentage of blood volume in each voxel, were higher in the brain regions than in extracerebral tissue. Hypocapnia (P(a)CO2 ≃ 25 mmHg) resulted in a significant decrease in CBV in the cerebellum (-17 ± 9%), in the corpus striatum (-15 ± 6%) and in the neocortex (-12±7%), compared to the normocapnic CBV values (group 1). These changes were in good agreement with the values obtained using alternative techniques. No significant changes in blood volume were found in extracerebral tissue. The CBV changes were reversed during the recovery period. In the left dorsoparietal neocortex, the reduction in LDF (group 2) induced by hypocapnia (-21 ± 8%) was in accordance with the values predicted by the Poiseuille's law. We conclude that rCBV changes during CO2 manipulation can be accurately measured by susceptibility contrast MRI. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish (US)
Pages (from-to)384-391
Number of pages8
JournalNMR in Biomedicine
Volume13
Issue number7
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Hypocapnia
Neocortex
Magnetic resonance imaging
Blood
Blood Volume
Corpus Striatum
Cerebellum
Cerebrovascular Circulation
Lasers
Tissue
Flow measurement
Cerebral Blood Volume
Brain
Rats
Recovery

Keywords

  • Cerebral blood volume
  • Contrast agent
  • Hypocapnia
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI. / Payen, Jean François; Briot, Emmanuel; Tropres, Irène; Julien-Dolbec, Cécile; Montigon, Olivier; Decorps, Michel.

In: NMR in Biomedicine, Vol. 13, No. 7, 2000, p. 384-391.

Research output: Contribution to journalArticle

Payen, Jean François ; Briot, Emmanuel ; Tropres, Irène ; Julien-Dolbec, Cécile ; Montigon, Olivier ; Decorps, Michel. / Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI. In: NMR in Biomedicine. 2000 ; Vol. 13, No. 7. pp. 384-391.
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