Regional cerebral blood flow is not decreased in young adults with Down syndrome

M. B. Schapiro, K. F. Berman, Daniel Weinberger, S. I. Rapoport

Research output: Contribution to journalArticle

Abstract

An index of regional cerebral blood flow (rCBF) of cortical gray matter, initial slope (IS), was measured with the noninvasive xenon-133 inhalation method on 2 consecutive days in 11 healthy, noninstitutionalized subjects with trisomy 21 Down syndrome (DS) (mean age 28.0 years) and in 22 sex-matched, healthy volunteers (mean age 27.3 years). IS did not differ between groups for any lobar region. The ratio of rIS to hemispheric IS, and right/left and frontal/nonfrontal ratios also failed to show significant regional differences between groups. These results show that healthy young DS adults do not show abnormalities in rCBF, as measured with xenon-133 clearance, prior to the age (35 years) when neuropathological changes of Alzheimer's disease are reported to occur.

Original languageEnglish (US)
Pages (from-to)310-315
Number of pages6
JournalBrain Dysfunction
Volume2
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Down Syndrome
Young Adult
Xenon
Healthy Volunteers
Inhalation
Alzheimer Disease

Keywords

  • Brain
  • Cerebral blood flow
  • Down syndrome
  • Mental retardation
  • Trisomy 21
  • Xenon-133

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Schapiro, M. B., Berman, K. F., Weinberger, D., & Rapoport, S. I. (1989). Regional cerebral blood flow is not decreased in young adults with Down syndrome. Brain Dysfunction, 2(6), 310-315.

Regional cerebral blood flow is not decreased in young adults with Down syndrome. / Schapiro, M. B.; Berman, K. F.; Weinberger, Daniel; Rapoport, S. I.

In: Brain Dysfunction, Vol. 2, No. 6, 1989, p. 310-315.

Research output: Contribution to journalArticle

Schapiro, MB, Berman, KF, Weinberger, D & Rapoport, SI 1989, 'Regional cerebral blood flow is not decreased in young adults with Down syndrome', Brain Dysfunction, vol. 2, no. 6, pp. 310-315.
Schapiro, M. B. ; Berman, K. F. ; Weinberger, Daniel ; Rapoport, S. I. / Regional cerebral blood flow is not decreased in young adults with Down syndrome. In: Brain Dysfunction. 1989 ; Vol. 2, No. 6. pp. 310-315.
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