Abstract
An index of regional cerebral blood flow (rCBF) of cortical gray matter, initial slope (IS), was measured with the noninvasive xenon-133 inhalation method on 2 consecutive days in 11 healthy, noninstitutionalized subjects with trisomy 21 Down syndrome (DS) (mean age 28.0 years) and in 22 sex-matched, healthy volunteers (mean age 27.3 years). IS did not differ between groups for any lobar region. The ratio of rIS to hemispheric IS, and right/left and frontal/nonfrontal ratios also failed to show significant regional differences between groups. These results show that healthy young DS adults do not show abnormalities in rCBF, as measured with xenon-133 clearance, prior to the age (35 years) when neuropathological changes of Alzheimer's disease are reported to occur.
Original language | English (US) |
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Pages (from-to) | 310-315 |
Number of pages | 6 |
Journal | Brain Dysfunction |
Volume | 2 |
Issue number | 6 |
State | Published - Dec 1 1989 |
Externally published | Yes |
Keywords
- Brain
- Cerebral blood flow
- Down syndrome
- Mental retardation
- Trisomy 21
- Xenon-133
ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology