Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder

Elizabeth A. Osuch, Brenda Benson, Marilla Geraci, Daniel Podell, Peter Herscovitch, Una D McCann, Robert M. Post

Research output: Contribution to journalArticle

Abstract

Background: Nuclear imaging studies have examined cerebral blood flow (rCBF) in subjects with posttraumatic stress disorder (PTSD) using symptom evocation paradigms. To date, no such studies have investigated rCBF as related to subjects' reports of flashback intensity. Methods: Subjects with varying traumatic histories and longstanding PTSD were studied using [15O]-H2O positron emission tomography with an auditory script of their traumatic event. Eight subjects had three resting scans followed by their script and additional scans. Heart rate responses as well as the presence of flashbacks and their intensity were recorded. rCBF was correlated with flashback intensity in each subject's scan. Combined analysis of all subjects' data yielded common regions related to the flashback experience. Results: rCBF correlated directly with flashback intensity in the brainstem, lingula, bilateral insula, right putamen and left hippocampal and perihippocampal, somatosensory and cerebellar regions. Inverse correlations with rCBF were found in bilateral dorsolateral prefrontal, right fusiform and right medial temporal cortices. Conclusions: This study correlated flashback intensity and rCBF in a group of patients with chronic PTSD suggesting involvement of brainstem, and areas associated with motor control, complex visual/spatial cues and memory.

Original languageEnglish (US)
Pages (from-to)246-253
Number of pages8
JournalBiological Psychiatry
Volume50
Issue number4
DOIs
StatePublished - Aug 15 2001

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Cerebrovascular Circulation
Regional Blood Flow
Post-Traumatic Stress Disorders
Brain Stem
Putamen
Temporal Lobe
Positron-Emission Tomography
Cues
Heart Rate

Keywords

  • Cerebral perfusion
  • Functional neuroimaging
  • PET
  • PTSD
  • Trauma provocation

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder. / Osuch, Elizabeth A.; Benson, Brenda; Geraci, Marilla; Podell, Daniel; Herscovitch, Peter; McCann, Una D; Post, Robert M.

In: Biological Psychiatry, Vol. 50, No. 4, 15.08.2001, p. 246-253.

Research output: Contribution to journalArticle

Osuch, Elizabeth A. ; Benson, Brenda ; Geraci, Marilla ; Podell, Daniel ; Herscovitch, Peter ; McCann, Una D ; Post, Robert M. / Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder. In: Biological Psychiatry. 2001 ; Vol. 50, No. 4. pp. 246-253.
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