Regenerative Stromal Cell Therapy in Allogeneic Hematopoietic Stem Cell Transplantation: Current Impact and Future Directions

Jeffery J. Auletta, Kenneth R. Cooke, Luis A. Solchaga, Robert J. Deans, Wouter van't Hof

Research output: Contribution to journalReview articlepeer-review

Abstract

Regenerative stromal cell therapy (RSCT) has the potential to become a novel therapy for preventing and treating acute graft-versus-host disease (GVHD) in the allogeneic hematopoietic stem cell transplant (HSCT) recipient. However, enthusiasm for using RSCT in allogeneic HSCT has been tempered by limited clinical data and poorly defined in vivo mechanisms of action. As a result, the full clinical potential of RSCT in supporting hematopoietic reconstitution and as treatment for GVHD remains to be determined. This manuscript reviews the immunomodulatory activity of regenerative stromal cells in preclinical models of allogeneic HSCT, and emphasizes an emerging literature suggesting that microenvironment influences RSC activation and function. Understanding this key finding may ultimately define the proper niche for RSCT in allogeneic HSCT. In particular, mechanistic studies are needed to delineate the in vivo effects of RSCT in response to inflammation and injury associated with allogeneic HSCT, and to define the relevant sites of RSC interaction with immune cells in the transplant recipient. Furthermore, development of in vivo imaging technology to correlate biodistribution patterns, desired RSC effect, and clinical outcome will be crucial to establishing dose-response effects and minimal biologic dose thresholds needed to advance translational treatment strategies for complications like GVHD.

Original languageEnglish (US)
Pages (from-to)891-906
Number of pages16
JournalBiology of Blood and Marrow Transplantation
Volume16
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation
  • Immunomodulation
  • Mesenchymal stem cell
  • Microenvironment
  • Multipotent adult progenitor cell
  • Rgenerative stromal cell therapy

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint

Dive into the research topics of 'Regenerative Stromal Cell Therapy in Allogeneic Hematopoietic Stem Cell Transplantation: Current Impact and Future Directions'. Together they form a unique fingerprint.

Cite this