Regenerative medicine for the heart: Perspectives on stem-cell therapy

Gun Sik Cho, Laviel Fernandez, Chulan Kwon

Research output: Contribution to journalArticle

Abstract

Significance: Despite decades of progress in cardiovascular biology and medicine, heart disease remains the leading cause of death, and there is no cure for the failing heart. Since heart failure is mostly caused by loss or dysfunction of cardiomyocytes (CMs), replacing dead or damaged CMs with new CMs might be an ideal way to reverse the disease. However, the adult heart is composed mainly of terminally differentiated CMs that have no significant self-regeneration capacity. Recent Advances: Stem cells have tremendous regenerative potential and, thus, current cardiac regenerative research has focused on developing stem cell sources to repair damaged myocardium. Critical Issues: In this review, we examine the potential sources of cells that could be used for heart therapies, including embryonic stem cells and induced pluripotent stem cells, as well as alternative methods for activating the endogenous regenerative mechanisms of the heart via transdifferentiation and cell reprogramming. We also discuss the current state of knowledge of cell purification, delivery, and retention. Future Directions: Efforts are underway to improve the current stem cell strategies and methodologies, which will accelerate the development of innovative stem-cell therapies for heart regeneration. Antioxid. Redox Signal. 21, 2018-2031.

Original languageEnglish (US)
Pages (from-to)2018-2031
Number of pages14
JournalAntioxidants and Redox Signaling
Volume21
Issue number14
DOIs
StatePublished - Nov 10 2014

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Regenerative Medicine
Cell- and Tissue-Based Therapy
Stem cells
Stem Cells
Cardiac Myocytes
Regeneration
Induced Pluripotent Stem Cells
Embryonic Stem Cells
Oxidation-Reduction
Cause of Death
Heart Diseases
Myocardium
Heart Failure
Medicine
Purification
Repair
Research

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry
  • Medicine(all)

Cite this

Regenerative medicine for the heart : Perspectives on stem-cell therapy. / Cho, Gun Sik; Fernandez, Laviel; Kwon, Chulan.

In: Antioxidants and Redox Signaling, Vol. 21, No. 14, 10.11.2014, p. 2018-2031.

Research output: Contribution to journalArticle

Cho, Gun Sik ; Fernandez, Laviel ; Kwon, Chulan. / Regenerative medicine for the heart : Perspectives on stem-cell therapy. In: Antioxidants and Redox Signaling. 2014 ; Vol. 21, No. 14. pp. 2018-2031.
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