Regenerative cellular therapies for neurologic diseases

Michael Levy, Nicholas Boulis, Mahendra Rao, Clive N. Svendsen

Research output: Contribution to journalArticlepeer-review

Abstract

The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson's disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which trials are currently active: demyelinating diseases/spinal cord injury, amyotrophic lateral sclerosis, stroke, Parkinson's disease, Huntington's disease, macular degeneration and peripheral nerve diseases. This article is part of a Special Issue entitled SI: PSC and the brain.

Original languageEnglish (US)
Pages (from-to)88-96
Number of pages9
JournalBrain research
Volume1638
DOIs
StatePublished - May 1 2016

Keywords

  • Neurologic disease
  • Regeneration
  • Stem cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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