Regeneration of oligodendroglia during recovery from demyelinating disease

Robert M. Herndon, Donald L. Price, Leslie P. Weiner

Research output: Contribution to journalArticlepeer-review

Abstract

Infection of mice with the JHM strain of mouse hepatitis virus causes demyelination as a result of a cytolytic infection of oligodendroglia. In recovery, animals show remyelination, which could result either from surviving oligodendrocytes extending their territory or by generation of new oligodendroglia. Electron microscopic autoradiographic studies with 3H-labeled thymidine demonstrate that the cells associated with remyelination are newly generated oligodendroglia.

Original languageEnglish (US)
Pages (from-to)693-694
Number of pages2
JournalScience
Volume195
Issue number4279
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • General

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