Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo

Crista Brawley, Erika Matunis

Research output: Contribution to journalArticlepeer-review

Abstract

Although the ability of engrafted stem cells to regenerate tissue has received much attention, the molecular mechanisms controlling regeneration are poorly understood. In the Drosophila mate germline, local activation of the Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway maintains stem cells; germline stem cells lacking Jak-STAT signaling differentiate into spermatogonia without self-renewal. By conditionally manipulating Jak-STAT signaling, we find that spermatogonia that have initiated differentiation and are undergoing limited mitotic (transit-amplifying) divisions can repopulate the niche and revert to stem cell identity. Thus, in the appropriate microenvironment, transit-amplifying cells dedifferentiate, becoming functional stem cells during tissue regeneration.

Original languageEnglish (US)
Pages (from-to)1331-1334
Number of pages4
JournalScience
Volume304
Issue number5675
DOIs
StatePublished - May 28 2004

ASJC Scopus subject areas

  • General

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