Regenerating matrix-based therapy for chronic wound healing: A prospective within-subject pilot study

Suzanne L. Groah, Alexander Libin, Miriam Spungen, Kim Loan Nguyen, Earthaleen Woods, Marjan Nabili, Jessica Ramella-Roman, Denis Barritault

Research output: Contribution to journalArticle

Abstract

The aim of this study was to determine whether a skin-specific bioengineered regenerating agent (RGTA) heparan sulphate mimetic (CACIPLIQ20) improves chronic wound healing. The design of this article is a prospective within-subject study. The setting was an urban hospital. Patients were 16 African-American individuals (mean age 42 years) with 22 wounds (mean duration 2·5 years) because of either pressure, diabetic, vascular or burn wounds. Two participants each were lost to follow-up or removed because of poor compliance, resulting in 18 wounds analysed. Sterile gauze was soaked with CACIPLIQ20 saline solution, placed on the wound for 5 min, then removed twice weekly for 4 weeks. Wounds were otherwise treated according to the standard of care. Twenty-two percent of wounds fully healed during the treatment period. Wounds showed a 15·2-18·1% decrease in wound size as measured by the vision engineering research group (VERG) digital wound measurement system and total PUSH scores, respectively, at 4 weeks (P = 0·014 and P = 0·003). At 8 weeks there was an 18-26% reduction in wound size (P = 0·04) in the remaining patients. Wound-related pain measured by the visual analogue pain scale and the wound pain scale declined 60% (P = 0·024) and 70% (P = 0·001), respectively. Patient and clinician satisfaction remained positive throughout the treatment period. It is concluded that treatment with CACIPLIQ20 significantly improved wound-related pain and may facilitate wound healing. Patient and clinician satisfaction remained high throughout the trial.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalInternational Wound Journal
Volume8
Issue number1
DOIs
StatePublished - Feb 2011
Externally publishedYes

Keywords

  • Glycosaminoglycans
  • Heparan sulphate
  • Wound healing
  • Wound pain

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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  • Cite this

    Groah, S. L., Libin, A., Spungen, M., Nguyen, K. L., Woods, E., Nabili, M., Ramella-Roman, J., & Barritault, D. (2011). Regenerating matrix-based therapy for chronic wound healing: A prospective within-subject pilot study. International Wound Journal, 8(1), 85-95. https://doi.org/10.1111/j.1742-481X.2010.00748.x